Abstract
Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1-1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.
Original language | English |
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Pages (from-to) | 103-104 |
Number of pages | 2 |
Journal | European Journal of Pharmacology |
Volume | 223 |
Issue number | 1 |
DOIs | |
Publication status | Published - 13 Nov 1992 |
Keywords
- Gastric mucosa
- Mucus
- Nitric oxide (NO)