Nitric oxide donors increase mucus gel thickness in rat stomach

James F. Brown, Peter J. Hanson, Brendan J. R. Whittle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1-1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

Original languageEnglish
Pages (from-to)103-104
Number of pages2
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - 13 Nov 1992


  • Gastric mucosa
  • Mucus
  • Nitric oxide (NO)


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