Nitric oxide donors increase mucus gel thickness in rat stomach

James F. Brown; Peter J. Hanson; Brendan J. R. Whittle

doi:10.1016/0014-2999(92)90824-N

Nitric oxide donors increase mucus gel thickness in rat stomach

James F. Brown, Peter J. Hanson, Brendan J. R. Whittle^*

^*Corresponding author for this work

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1-1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

Original language	English
Pages (from-to)	103-104
Number of pages	2
Journal	European Journal of Pharmacology
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(92)90824-N
Publication status	Published - 13 Nov 1992

Keywords

Gastric mucosa
Mucus
Nitric oxide (NO)

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10.1016/0014-2999(92)90824-N

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title = "Nitric oxide donors increase mucus gel thickness in rat stomach",

abstract = "Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1-1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.",

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AU - Brown, James F.

AU - Hanson, Peter J.

AU - Whittle, Brendan J. R.

PY - 1992/11/13

Y1 - 1992/11/13

N2 - Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1-1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

AB - Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1-1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

KW - Gastric mucosa

KW - Mucus

KW - Nitric oxide (NO)

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JF - European Journal of Pharmacology

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Nitric oxide donors increase mucus gel thickness in rat stomach

Abstract

Keywords

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