Noncoding RNAs and Duchenne muscular dystrophy

Mark M. Perry, Francesco Muntoni

Research output: Contribution to journalArticlepeer-review

101 Downloads (Pure)

Abstract

Noncoding RNAs (ncRNAs) such as miRNAs and long noncoding RNAs modulate gene transcription in response to environmental stressors and other stimuli. A role for ncRNAs in muscle pathologies has been demonstrated and further evidence suggests that ncRNAs also play a role in Duchenne muscular dystrophy (DMD). Studies investigating the differential expression of miRNAs in biological fluids between DMD patients and models of dystrophin deficiency (the MDX mouse model, canine models of DMD) and controls have been published, as these have a role in fibrosis. Long noncoding RNAs are differentially expressed in DMD patients and may, in part, have a mechanism of action via targeting of miRNAs. Although many of these recent findings need to be confirmed, ncRNAs may prove to be useful as potential biomarkers of disease. However, their use as therapeutic targets in DMD remains unclear.
Original languageEnglish
Pages (from-to)1527-1537
JournalEpigenomics
Volume8
Issue number11
Early online date7 Sep 2016
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

Fingerprint

Dive into the research topics of 'Noncoding RNAs and Duchenne muscular dystrophy'. Together they form a unique fingerprint.

Cite this