Optimization of large-scale manufacturing of biopolymeric and lipid nanoparticles using microfluidic swirl mixers

Mhd Anas Tomeh, Mohamad Hawari Mansor, Roja Hadianamrei, Weizhen Sun, Xiubo Zhao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Nanoparticles (NPs) have great potential as efficient drug delivery systems (DDSs) that have been widely used in cancer therapy and vaccines especially in the past decade. The rise in demand from the pharmaceutical industry drives the growth of the global NPs market. However, complex production processes have hindered the market growth. Therefore, the development of advanced preparation techniques such as microfluidics is required to improve productivity and controllability. In this study, we present a novel microfluidic design (swirl mixer) that helps accelerating the translation of many DDSs from laboratory to clinical application. The new swirl mixer provides high production rate, reproducibility, and precise control of particle size with low polydispersity index (PDI). To assess the performance of the swirl mixer, two different types of nanoformulations were used: silk nanoparticles (SNPs) and lipid nanoparticles (LNPs). The microfluidic device produced NPs efficiently with high productivity and allowed for tuning the mean size and size distribution by changing multiple processing parameters.
Original languageEnglish
Article number121762
Number of pages11
JournalInternational Journal of Pharmaceutics
Early online date28 Apr 2022
Publication statusPublished - 25 May 2022


  • Microfluidic
  • Swirl mixer
  • Nanoparticle manufacturing
  • Silk fibroin
  • Lipid nanoparticles
  • Drug delivery
  • Doxorubicin
  • UKRI
  • EP/N007174/1
  • EP/N023579/1

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