Self-nanoemulsifying drug delivery systems (SNEDDs) prepared from GRAS excipients (Labrafil M1944CS: Labrasol: Capryol 90: BPQ 30: 59 : 10 : 1% w/w/w/w) enhance the oral bioavailability of a poorly soluble antiparasitic drug, Buparvaquone (BPQ), while maintaining in vitro efficacy against L. infantum promastigotes. BPQ-SNEDDs possess high loading and excellent stability to tropical temperatures while allowing for the complete dissolution of BPQ in simulated gastrointestinal media. We hypothesise that the enhanced solubilisation capacity of BPQ in the GI tract is responsible for the enhanced oral bioavailability. Adsorption of prepared BPQ-SNEDDs on solid carriers (glycol chitosan) and lyophilisation resulted in a solid nanomedicine that can be reconstituted to yield stable BPQ-SNEDDs of nanomolar in vitro activity.
|Publication status||Published - 15 Jul 2014|
|Event||CRS Annual Meeting and Exposition - Chicago Hilton, Chicago, Illinois, United States|
Duration: 12 Jul 2014 → 16 Jul 2014
|Conference||CRS Annual Meeting and Exposition|
|Period||12/07/14 → 16/07/14|