Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels: regulation by acute hypoxia

Paul Kemp, Chris Peers, Anthony Lewis

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Although O2-sensitive tissues express a wide variety of channel types (Lopez-Barneo et al. 2001; Peers & Kemp, 2001), central to the cellular mechanism of O2 sensing in many is hypoxic suppression of large conductance Ca2+-activated K+ channels (maxiK, BKCa or Slo channels). Thus, hypoxic inhibition of maxiK channels has been demonstrated in carotid body (Peers, 1990; Pardal et al. 2000; Riesco-Fagundo et al. 2001), pulmonary smooth muscle (Cornfield et al. 1996), chromaffin cells (Thompson & Nurse, 1998), and other non-chemosensory tissues such as central neurones (Liu et al. 1999; Jiang & Haddad, 1994b). Contribution of this channel type to carotid body, chromatin cell and central neuronal function is well supported although some controversy still surrounds their involvement in pulmonary vasoconstriction (Ward & Aaronson, 1999) where there is also good evidence for both delayed rectifier (Tristani-Firouzi et al. 1996) and tandem P domain K+ channels in the response (Gurney et al. 2002); the later observation is fully supported by our recent report of O2 sensitivity of the tandem P domain channel, hTASKl, in a recombinant mammalian system similar to that employed in the present study (Lewis et al., 2001).
Original languageEnglish
Title of host publicationChemoreception: From Cellular Signalling to Functional Plasticity
EditorsJean Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yevette Dalmaz
Place of PublicationNew York
Number of pages7
ISBN (Electronic)9781441992802
ISBN (Print)9780306478680, 9781461348733
Publication statusPublished - 1 Jan 2003
EventXVth International Symposium on Arterial Chemorecption - Lyon, France
Duration: 18 Nov 200222 Nov 2002

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


ConferenceXVth International Symposium on Arterial Chemorecption


  • carotid body
  • acute hypoxia
  • pulmonary artery smooth muscle cell
  • asymmetrical solution
  • cytosolic factor

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