Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels: regulation by acute hypoxia

Paul Kemp, Chris Peers, Anthony Lewis

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Although O2-sensitive tissues express a wide variety of channel types (Lopez-Barneo et al. 2001; Peers & Kemp, 2001), central to the cellular mechanism of O2 sensing in many is hypoxic suppression of large conductance Ca2+-activated K+ channels (maxiK, BKCa or Slo channels). Thus, hypoxic inhibition of maxiK channels has been demonstrated in carotid body (Peers, 1990; Pardal et al. 2000; Riesco-Fagundo et al. 2001), pulmonary smooth muscle (Cornfield et al. 1996), chromaffin cells (Thompson & Nurse, 1998), and other non-chemosensory tissues such as central neurones (Liu et al. 1999; Jiang & Haddad, 1994b). Contribution of this channel type to carotid body, chromatin cell and central neuronal function is well supported although some controversy still surrounds their involvement in pulmonary vasoconstriction (Ward & Aaronson, 1999) where there is also good evidence for both delayed rectifier (Tristani-Firouzi et al. 1996) and tandem P domain K+ channels in the response (Gurney et al. 2002); the later observation is fully supported by our recent report of O2 sensitivity of the tandem P domain channel, hTASKl, in a recombinant mammalian system similar to that employed in the present study (Lewis et al., 2001).
Original languageEnglish
Title of host publicationChemoreception: From Cellular Signalling to Functional Plasticity
EditorsJean Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yevette Dalmaz
Place of PublicationNew York
PublisherSpringer
Pages209-215
Number of pages7
ISBN (Electronic)9781441992802
ISBN (Print)9780306478680, 9781461348733
DOIs
Publication statusPublished - 1 Jan 2003
EventXVth International Symposium on Arterial Chemorecption - Lyon, France
Duration: 18 Nov 200222 Nov 2002

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Number536
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Conference

ConferenceXVth International Symposium on Arterial Chemorecption
Country/TerritoryFrance
CityLyon
Period18/11/0222/11/02

Keywords

  • carotid body
  • acute hypoxia
  • pulmonary artery smooth muscle cell
  • asymmetrical solution
  • cytosolic factor

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