Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda

Domimique A. Caugant; Carole Fogg; Francis Bajunirwe; Patrice Piola; Roger Twesigye; Fred Mutebi; L. Oddvar Froholm; Einar Rosenqvist; Vincent Batwala; Ingeborg S. Aaberge; John-Arne Rottingen; Philippe J. Guerin

doi:10.1016/j.trstmh.2006.01.004

Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda

Domimique A. Caugant, Carole Fogg, Francis Bajunirwe, Patrice Piola, Roger Twesigye, Fred Mutebi, L. Oddvar Froholm, Einar Rosenqvist, Vincent Batwala, Ingeborg S. Aaberge, John-Arne Rottingen, Philippe J. Guerin

School of Health & Care Professions

Research output: Contribution to journal › Article › peer-review

Abstract

In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2–19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.

Original language	English
Pages (from-to)	1159-1163
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	100
Issue number	12
DOIs	https://doi.org/10.1016/j.trstmh.2006.01.004
Publication status	Published - Dec 2006

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Caugant, D. A., Fogg, C., Bajunirwe, F., Piola, P., Twesigye, R., Mutebi, F., Froholm, L. O., Rosenqvist, E., Batwala, V., Aaberge, I. S., Rottingen, J-A., & Guerin, P. J. (2006). Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(12), 1159-1163. https://doi.org/10.1016/j.trstmh.2006.01.004

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title = "Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda",

abstract = "In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2–19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.",

author = "Caugant, {Domimique A.} and Carole Fogg and Francis Bajunirwe and Patrice Piola and Roger Twesigye and Fred Mutebi and Froholm, {L. Oddvar} and Einar Rosenqvist and Vincent Batwala and Aaberge, {Ingeborg S.} and John-Arne Rottingen and Guerin, {Philippe J.}",

year = "2006",

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doi = "10.1016/j.trstmh.2006.01.004",

language = "English",

volume = "100",

pages = "1159--1163",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

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Caugant, DA, Fogg, C, Bajunirwe, F, Piola, P, Twesigye, R, Mutebi, F, Froholm, LO, Rosenqvist, E, Batwala, V, Aaberge, IS, Rottingen, J-A & Guerin, PJ 2006, 'Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 12, pp. 1159-1163. https://doi.org/10.1016/j.trstmh.2006.01.004

TY - JOUR

T1 - Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda

AU - Caugant, Domimique A.

AU - Fogg, Carole

AU - Bajunirwe, Francis

AU - Piola, Patrice

AU - Twesigye, Roger

AU - Mutebi, Fred

AU - Froholm, L. Oddvar

AU - Rosenqvist, Einar

AU - Batwala, Vincent

AU - Aaberge, Ingeborg S.

AU - Rottingen, John-Arne

AU - Guerin, Philippe J.

PY - 2006/12

Y1 - 2006/12

N2 - In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2–19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.

AB - In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2–19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.

U2 - 10.1016/j.trstmh.2006.01.004

DO - 10.1016/j.trstmh.2006.01.004

M3 - Article

SN - 0035-9203

VL - 100

SP - 1159

EP - 1163

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 12

ER -

Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda

Abstract

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