TY - JOUR
T1 - Pharyngeal carriage of Neisseria meningitidis in 2–19-year-old individuals in Uganda
AU - Caugant, Domimique A.
AU - Fogg, Carole
AU - Bajunirwe, Francis
AU - Piola, Patrice
AU - Twesigye, Roger
AU - Mutebi, Fred
AU - Froholm, L. Oddvar
AU - Rosenqvist, Einar
AU - Batwala, Vincent
AU - Aaberge, Ingeborg S.
AU - Rottingen, John-Arne
AU - Guerin, Philippe J.
PY - 2006/12
Y1 - 2006/12
N2 - In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2–19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.
AB - In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2–19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.
U2 - 10.1016/j.trstmh.2006.01.004
DO - 10.1016/j.trstmh.2006.01.004
M3 - Article
SN - 0035-9203
VL - 100
SP - 1159
EP - 1163
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 12
ER -