The question of whether discernible differences exist between liars and truth tellers has interested professional lie detectors and laypersons for centuries. In this article we discuss whether people can detect lies when observing someone’s nonverbal behavior or analyzing someone’s speech. An article about detecting lies by observing nonverbal and verbal cues is overdue. Scientific journals regularly publish overviews of research articles regarding nonverbal and verbal cues to deception, but they offer no explicit guidance about what lie detectors should do and should avoid doing to catch liars. We will present such guidance in the present article.