Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation

L. Dusse, D. Rios, M. Pinheiro, Alan Cooper, B. Lwaleed

Research output: Contribution to journalArticlepeer-review

Abstract

Pre-eclampsia (PE) is a multi-system disorder of human pregnancy, characterised by hypertension and proteinuria. Although the pathogenesis of PE is not fully understood, predisposition to endothelial dysfunction is thought to play a crucial part. Despite intensive research there is no reliable test for screening purposes or to inform decision making towards effective treatment for PE. Understanding the link between PE, abnormal haemostatic activation and inflammation may help to elucidate some of the patho-physiology of the disease; primary preventative measures and targeted therapies at an early stage of the disease could then be considered. In the present paper we discuss potential causal links between PE, haemostasis and inflammation. The potential implications of such interaction on the pathogenesis of PE are also addressed.
Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalClinica Chimica Acta
Volume412
Issue number1-2
DOIs
Publication statusPublished - 2011

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