Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration: effect of concentration and molecular weigh

Christina Karavasili, Orestis Katsamenis, Nikolaos Bouropoulos, Hamde Nazar, Philipp Thurner, Marisa Van Der Merwe, Dimitrios Fatouros

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Abstract

Toward the development of microparticulate carriers for nasal administration, N-trimethylchitosan chloride (TMC) of low molecular weight (LMW) and high molecular weight (HMW) and low degree of quaternization (16% and 27%, respectively) was co-formulated into microparticles comprising of dipalmatoylphosphatidylcholine (DPPC) and poly(lactic-co-glycolic) acid (PLGA) via the spray-drying technique. The chitosan derivatives were characterized by means of nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transfrom infrared (FTIR) spectroscopy. The size and morphology of the produced microparticles were assessed by scanning electron microscopy (SEM), whereas their mucoadhesive properties were investigated by means of atomic force microscopy–force spectroscopy (AFM-FS). The results showed that microparticles exhibit mucoadhesion when TMC is present on their surface above a threshold of TMC (>0.3% w/w).
Original languageEnglish
Pages (from-to)12337–12344
JournalLangmuir
Volume30
Issue number41
Early online date23 Sep 2014
DOIs
Publication statusPublished - 7 Oct 2014

Keywords

  • Nasal delivery, chitosan derivatives, mucoadhesion, Atomic force microscopy

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