TY - JOUR
T1 - Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration
T2 - effect of concentration and molecular weigh
AU - Karavasili, Christina
AU - Katsamenis, Orestis
AU - Bouropoulos, Nikolaos
AU - Nazar, Hamde
AU - Thurner, Philipp
AU - Van Der Merwe, Marisa
AU - Fatouros, Dimitrios
N1 - Supplementary information submitted as a separate file as is required by journal.
“This document is the Accepted Manuscript version of a Published Work that appeared in final form in
'Langmuir', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/la5030636
PY - 2014/10/7
Y1 - 2014/10/7
N2 - Toward the development of microparticulate carriers for nasal administration, N-trimethylchitosan chloride (TMC) of low molecular weight (LMW) and high molecular weight (HMW) and low degree of quaternization (16% and 27%, respectively) was co-formulated into microparticles comprising of dipalmatoylphosphatidylcholine (DPPC) and poly(lactic-co-glycolic) acid (PLGA) via the spray-drying technique. The chitosan derivatives were characterized by means of nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transfrom infrared (FTIR) spectroscopy. The size and morphology of the produced microparticles were assessed by scanning electron microscopy (SEM), whereas their mucoadhesive properties were investigated by means of atomic force microscopy–force spectroscopy (AFM-FS). The results showed that microparticles exhibit mucoadhesion when TMC is present on their surface above a threshold of TMC (>0.3% w/w).
AB - Toward the development of microparticulate carriers for nasal administration, N-trimethylchitosan chloride (TMC) of low molecular weight (LMW) and high molecular weight (HMW) and low degree of quaternization (16% and 27%, respectively) was co-formulated into microparticles comprising of dipalmatoylphosphatidylcholine (DPPC) and poly(lactic-co-glycolic) acid (PLGA) via the spray-drying technique. The chitosan derivatives were characterized by means of nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transfrom infrared (FTIR) spectroscopy. The size and morphology of the produced microparticles were assessed by scanning electron microscopy (SEM), whereas their mucoadhesive properties were investigated by means of atomic force microscopy–force spectroscopy (AFM-FS). The results showed that microparticles exhibit mucoadhesion when TMC is present on their surface above a threshold of TMC (>0.3% w/w).
KW - Nasal delivery, chitosan derivatives, mucoadhesion, Atomic force microscopy
U2 - 10.1021/la5030636
DO - 10.1021/la5030636
M3 - Article
VL - 30
SP - 12337
EP - 12344
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 41
ER -