Preparation and characterization of multiactive electrospun fibers: Poly-ɛ-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs: multiactive electrospun fibers

Chirstina Karavasili, Nikolaos Bouropoulos, Ioanna Kontopoulou, Ashleigh Smith, Marisa Van Der Merwe, Ihtesham U. R. Rehman, Zeeshan Ahmad, Dimitrios G. Fatouros

Research output: Contribution to journalArticlepeer-review

Abstract

Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 µm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications.
Original languageEnglish
Pages (from-to)2583-2589
JournalJournal of Biomedical Materials Research Part A
Volume102
Issue number8
Early online date2 Sept 2013
DOIs
Publication statusPublished - Aug 2014

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