Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy

Sreedhari Thayalasekaran, Rupam Bhattacharyya, Fergus Chedgy, Peter Basford, Sharmila Subramaniam, Kesavan Kandiah, Fergus Thursby‐pelham, James Brown, Asma Alkandari, Richard Ellis, Sergio Coda, Patrick Goggin, Mark Amos, Carole Fogg, Gaius Longcroft‐wheaton, Pradeep Bhandari

Research output: Contribution to journalArticlepeer-review

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Objectives: Endorings is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds.

Aims: Investigate if Endorings Colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC).

Methods: Multi-centre, parallel group, randomised controlled trial.

Results: Total of 556 patients randomised to ER (275) or SC (281). Colonoscopy completed 532/556 (96%) cases. EndoRings removed in 74/275 (27%) patients. Total number of polyps in ER limb 582 vs 515 in SC limb, p=0.04. Total number of adenomas in ER limb 361 vs 343 for SC limb, p=0.49. A statistically significant difference in the mean number of polyps per patient in both the Intention to Treat (ITT) (1.84 SC vs 2.10 ER, p-value 0.027) and Per Protocol (PP) (1.84 SC vs 2.25 ER, p-value 0.004).

Conclusions: Our study shows promise for the EndoRings device to improve polyp detection.
Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalDigestive endoscopy
Issue number3
Early online date9 Sept 2022
Publication statusPublished - 1 Mar 2023


  • colonic neoplasm
  • colonic polyp
  • olonoscopy
  • human
  • Randomized Controlled Trial


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