Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy

Sreedhari Thayalasekaran; Rupam Bhattacharyya; Fergus Chedgy; Peter Basford; Sharmila Subramaniam; Kesavan Kandiah; Fergus Thursby‐pelham; James Brown; Asma Alkandari; Richard Ellis; Sergio Coda; Patrick Goggin; Mark Amos; Carole Fogg; Gaius Longcroft‐wheaton; Pradeep Bhandari

doi:10.1111/den.14432

Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy

Sreedhari Thayalasekaran, Rupam Bhattacharyya, Fergus Chedgy, Peter Basford, Sharmila Subramaniam, Kesavan Kandiah, Fergus Thursby‐pelham, James Brown, Asma Alkandari, Richard Ellis, Sergio Coda, Patrick Goggin, Mark Amos, Carole Fogg, Gaius Longcroft‐wheaton, Pradeep Bhandari

Institute of Life Sciences and Healthcare

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Abstract

Objectives: Endorings is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds.

Aims: Investigate if Endorings Colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC).

Methods: Multi-centre, parallel group, randomised controlled trial.

Results: Total of 556 patients randomised to ER (275) or SC (281). Colonoscopy completed 532/556 (96%) cases. EndoRings removed in 74/275 (27%) patients. Total number of polyps in ER limb 582 vs 515 in SC limb, p=0.04. Total number of adenomas in ER limb 361 vs 343 for SC limb, p=0.49. A statistically significant difference in the mean number of polyps per patient in both the Intention to Treat (ITT) (1.84 SC vs 2.10 ER, p-value 0.027) and Per Protocol (PP) (1.84 SC vs 2.25 ER, p-value 0.004).

Conclusions: Our study shows promise for the EndoRings device to improve polyp detection.

Original language	English
Pages (from-to)	354-360
Number of pages	7
Journal	Digestive endoscopy
Volume	35
Issue number	3
Early online date	9 Sept 2022
DOIs	https://doi.org/10.1111/den.14432
Publication status	Published - 1 Mar 2023

Keywords

colonic neoplasm
colonic polyp
olonoscopy
human
Randomized Controlled Trial

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10.1111/den.14432

A Randomised Controlled Trial of EndoRingsTM
This is the peer reviewed version of the following article: Thayalasekaran, S., Bhattacharyya, R., Chedgy, F., Basford, P., Subramaniam, S., Kandiah, K., Thursby-Pelham, F., Brown, J., Alkandari, A., Ellis, R., Coda, S., Goggin, P., Amos, M., Fogg, C., Longcroft-Wheaton, G. and Bhandari, P. (2022), A Randomised Controlled Trial of EndoRingsTM Assisted Colonoscopy Versus Standard Colonoscopy. Digestive Endoscopy. Accepted Author Manuscript. https://doi.org/10.1111/den.14432, which has been published in final form at https://doi.org/10.1111/den.14432.
Accepted author manuscript (Post-print), 436 KB

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Thayalasekaran, S., Bhattacharyya, R., Chedgy, F., Basford, P., Subramaniam, S., Kandiah, K., Thursby‐pelham, F., Brown, J., Alkandari, A., Ellis, R., Coda, S., Goggin, P., Amos, M., Fogg, C., Longcroft‐wheaton, G., & Bhandari, P. (2023). Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy. Digestive endoscopy, 35(3), 354-360. https://doi.org/10.1111/den.14432

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title = "Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy",

abstract = "Objectives: Endorings is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds. Aims: Investigate if Endorings Colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC). Methods: Multi-centre, parallel group, randomised controlled trial. Results: Total of 556 patients randomised to ER (275) or SC (281). Colonoscopy completed 532/556 (96\%) cases. EndoRings removed in 74/275 (27\%) patients. Total number of polyps in ER limb 582 vs 515 in SC limb, p=0.04. Total number of adenomas in ER limb 361 vs 343 for SC limb, p=0.49. A statistically significant difference in the mean number of polyps per patient in both the Intention to Treat (ITT) (1.84 SC vs 2.10 ER, p-value 0.027) and Per Protocol (PP) (1.84 SC vs 2.25 ER, p-value 0.004). Conclusions: Our study shows promise for the EndoRings device to improve polyp detection.",

keywords = "colonic neoplasm, colonic polyp, olonoscopy, human, Randomized Controlled Trial",

author = "Sreedhari Thayalasekaran and Rupam Bhattacharyya and Fergus Chedgy and Peter Basford and Sharmila Subramaniam and Kesavan Kandiah and Fergus Thursby‐pelham and James Brown and Asma Alkandari and Richard Ellis and Sergio Coda and Patrick Goggin and Mark Amos and Carole Fogg and Gaius Longcroft‐wheaton and Pradeep Bhandari",

note = "This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley{\textquoteright}s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.",

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language = "English",

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Thayalasekaran, S, Bhattacharyya, R, Chedgy, F, Basford, P, Subramaniam, S, Kandiah, K, Thursby‐pelham, F, Brown, J, Alkandari, A, Ellis, R, Coda, S, Goggin, P, Amos, M, Fogg, C, Longcroft‐wheaton, G & Bhandari, P 2023, 'Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy', Digestive endoscopy, vol. 35, no. 3, pp. 354-360. https://doi.org/10.1111/den.14432

TY - JOUR

T1 - Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy

AU - Thayalasekaran, Sreedhari

AU - Bhattacharyya, Rupam

AU - Chedgy, Fergus

AU - Basford, Peter

AU - Subramaniam, Sharmila

AU - Kandiah, Kesavan

AU - Thursby‐pelham, Fergus

AU - Brown, James

AU - Alkandari, Asma

AU - Ellis, Richard

AU - Coda, Sergio

AU - Goggin, Patrick

AU - Amos, Mark

AU - Fogg, Carole

AU - Longcroft‐wheaton, Gaius

AU - Bhandari, Pradeep

N1 - This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Objectives: Endorings is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds. Aims: Investigate if Endorings Colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC). Methods: Multi-centre, parallel group, randomised controlled trial. Results: Total of 556 patients randomised to ER (275) or SC (281). Colonoscopy completed 532/556 (96%) cases. EndoRings removed in 74/275 (27%) patients. Total number of polyps in ER limb 582 vs 515 in SC limb, p=0.04. Total number of adenomas in ER limb 361 vs 343 for SC limb, p=0.49. A statistically significant difference in the mean number of polyps per patient in both the Intention to Treat (ITT) (1.84 SC vs 2.10 ER, p-value 0.027) and Per Protocol (PP) (1.84 SC vs 2.25 ER, p-value 0.004). Conclusions: Our study shows promise for the EndoRings device to improve polyp detection.

AB - Objectives: Endorings is a distal attachment consisting of two layers of circular flexible rings that evert mucosal folds. Aims: Investigate if Endorings Colonoscopy (ER) improves polyp and adenoma detection compared to standard colonoscopy (SC). Methods: Multi-centre, parallel group, randomised controlled trial. Results: Total of 556 patients randomised to ER (275) or SC (281). Colonoscopy completed 532/556 (96%) cases. EndoRings removed in 74/275 (27%) patients. Total number of polyps in ER limb 582 vs 515 in SC limb, p=0.04. Total number of adenomas in ER limb 361 vs 343 for SC limb, p=0.49. A statistically significant difference in the mean number of polyps per patient in both the Intention to Treat (ITT) (1.84 SC vs 2.10 ER, p-value 0.027) and Per Protocol (PP) (1.84 SC vs 2.25 ER, p-value 0.004). Conclusions: Our study shows promise for the EndoRings device to improve polyp detection.

KW - colonic neoplasm

KW - colonic polyp

KW - olonoscopy

KW - human

KW - Randomized Controlled Trial

UR - https://www.scopus.com/pages/publications/85141353711

U2 - 10.1111/den.14432

DO - 10.1111/den.14432

M3 - Article

C2 - 36085410

SN - 0915-5635

VL - 35

SP - 354

EP - 360

JO - Digestive endoscopy

JF - Digestive endoscopy

IS - 3

ER -

Randomized controlled trial of EndoRings assisted colonoscopy versus standard colonoscopy

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Keywords

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