Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.
- Base Pairing
- Hydrogen Bonding
- Nucleic Acid Conformation
- Nucleosides/chemical synthesis
- Pyrimidinones/chemical synthesis