Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Rohan T. Ranasinghe; David A. Rusling; Vicki E. C. Powers; Keith R. Fox; Tom Brown

doi:10.1039/b502325d

Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Rohan T. Ranasinghe, David A. Rusling, Vicki E. C. Powers, Keith R. Fox, Tom Brown

School of Pharmacy & Biomedical Sciences

University Hospital Southampton NHS Foundation Trust

Research output: Contribution to journal › Review article › peer-review

Abstract

Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

Original language	English
Pages (from-to)	2555-2557
Number of pages	3
Journal	Chemical Communications
Issue number	20
DOIs	https://doi.org/10.1039/b502325d
Publication status	Published - 28 May 2005

Keywords

Base Pairing
Cytosine/analysis
DNA/chemistry
Guanine/analysis
Hydrogen Bonding
Nucleic Acid Conformation
Nucleosides/chemical synthesis
Oligonucleotides/chemistry
Pyrimidinones/chemical synthesis
Thymine/analysis

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10.1039/b502325d

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@article{1ac26310216e4efebdd41068d357fa20,

title = "Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues",

abstract = "Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.",

keywords = "Base Pairing, Cytosine/analysis, DNA/chemistry, Guanine/analysis, Hydrogen Bonding, Nucleic Acid Conformation, Nucleosides/chemical synthesis, Oligonucleotides/chemistry, Pyrimidinones/chemical synthesis, Thymine/analysis",

author = "Ranasinghe, {Rohan T.} and Rusling, {David A.} and Powers, {Vicki E. C.} and Fox, {Keith R.} and Tom Brown",

year = "2005",

month = may,

day = "28",

doi = "10.1039/b502325d",

language = "English",

pages = "2555--2557",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "20",

}

TY - JOUR

T1 - Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

AU - Ranasinghe, Rohan T.

AU - Rusling, David A.

AU - Powers, Vicki E. C.

AU - Fox, Keith R.

AU - Brown, Tom

PY - 2005/5/28

Y1 - 2005/5/28

N2 - Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

AB - Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

KW - Base Pairing

KW - Cytosine/analysis

KW - DNA/chemistry

KW - Guanine/analysis

KW - Hydrogen Bonding

KW - Nucleic Acid Conformation

KW - Nucleosides/chemical synthesis

KW - Oligonucleotides/chemistry

KW - Pyrimidinones/chemical synthesis

KW - Thymine/analysis

U2 - 10.1039/b502325d

DO - 10.1039/b502325d

M3 - Review article

C2 - 15900324

SN - 1359-7345

SP - 2555

EP - 2557

JO - Chemical Communications

JF - Chemical Communications

IS - 20

ER -

Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Abstract

Keywords

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