Abstract
Background
The reproducibility of cardiopulmonary exercise testing (CPET) has not been established in young cystic fibrosis (CF) patients using a valid protocol.
Methods
Thirteen 7–18 year olds completed three CPETs, separated by 48 h and 4–6 weeks. CPET involved a ramp-incremental cycling test with supramaximal verification.
Results
Maximal oxygen uptake was repeatedly determined with no learning effect and typical errors expressed as a coefficient of variation (TECV%) of 9.3% (48 h) and 13.3% (4–6 weeks). The reproducibility of additional parameters of aerobic function [gas exchange threshold (TECV%: 11.2%, 16.8%); View the MathML sourceO2 mean response time (TECV%: 37.8%, 89.4%); View the MathML sourceO2 gain (TECV%: 17.4%, 24.5%)] and clinical utility [e.g. SaO2% (TECV%: 2.2%, 3.1%); ventilatory drive (View the MathML sourceE/View the MathML sourceCO2-slope) (TECV%: 7.8%, 17.7%)] was also established over the short- and the medium-term, respectively.
Conclusion
These results establish limits of variability to determine meaningful changes over the short- and the medium-term for CPET outcomes in young CF patients.
The reproducibility of cardiopulmonary exercise testing (CPET) has not been established in young cystic fibrosis (CF) patients using a valid protocol.
Methods
Thirteen 7–18 year olds completed three CPETs, separated by 48 h and 4–6 weeks. CPET involved a ramp-incremental cycling test with supramaximal verification.
Results
Maximal oxygen uptake was repeatedly determined with no learning effect and typical errors expressed as a coefficient of variation (TECV%) of 9.3% (48 h) and 13.3% (4–6 weeks). The reproducibility of additional parameters of aerobic function [gas exchange threshold (TECV%: 11.2%, 16.8%); View the MathML sourceO2 mean response time (TECV%: 37.8%, 89.4%); View the MathML sourceO2 gain (TECV%: 17.4%, 24.5%)] and clinical utility [e.g. SaO2% (TECV%: 2.2%, 3.1%); ventilatory drive (View the MathML sourceE/View the MathML sourceCO2-slope) (TECV%: 7.8%, 17.7%)] was also established over the short- and the medium-term, respectively.
Conclusion
These results establish limits of variability to determine meaningful changes over the short- and the medium-term for CPET outcomes in young CF patients.
Original language | English |
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Pages (from-to) | 644-650 |
Journal | Journal of Cystic Fibrosis |
Volume | 12 |
Issue number | 6 |
Early online date | 28 May 2013 |
DOIs | |
Publication status | Published - Dec 2013 |