A retrosynthetic method has been developed to design the synthesis of target zeotypes whose frameworks belong to the ABC-6 structural family and which contain gme cages. This permits the preparation of silicoaluminophosphate versions of AFX (SAPO-56), SFW (STA-18), and GME (STA-19) topology types. The method makes simultaneous use of two organic structure-directing agents (SDAs) to promote the formation of structural features such as cages or channels of the target framework. Computational modeling was used to identify SDAs for gme and other cages or channels in the target structures. The trimethylammonium cation was found to be the most favorable SDA for the gme cage while bisdiazabicyclooctane (DABCO) alkane cations and quaternary ammonium oligomers of DABCO with connecting polymethylene chain lengths of 4–8 methylene units acted as templates for the additional cages or channels, respectively. The incorporation of each of the co-SDAs in the as-prepared materials was confirmed by chemical analysis, 13C MAS NMR, and Rietveld refinement combined with computational modeling. Calcination of the SAPO-56, STA-18, and some of the STA-19 materials gives microporous, fully tetrahedrally coordinated framework solids with AFX, SFW, and GME topologies: other STA-19 samples convert topotactically to SAPO-5. These results show that SAPOs in the ABC-6 family can be prepared via a targeted co-templating approach.