TY - JOUR
T1 - Risk of mortality in HIV-infected COVID-19 patients
T2 - a systematic review and meta-analysis
AU - Dzinamarira, Tafadzwa
AU - Murewanhema, Grant
AU - Chitungo, Itai
AU - Ngara, Bernard
AU - Nkambule, Sphamandla Josias
AU - Madziva, Roda
AU - Herrera, Helena
AU - Mukwenha, Solomon
AU - Cuadros, Diego F.
AU - Iradukunda, Patrick Gad
AU - Mashora, Moreblessing
AU - Tungwarara, Nigel
AU - Rwibasira, Gallican Nshogoza
AU - Musuka, Godfrey
N1 - Funding Information:
Not applicable.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger's test was employed to determine the risk of bias. Results: A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86–1.32). The between-studies heterogeneity was substantial (I2 = 91%, P < 0.01), while the risk of publication bias was not significant. Conclusion: Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection.
AB - Background: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger's test was employed to determine the risk of bias. Results: A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86–1.32). The between-studies heterogeneity was substantial (I2 = 91%, P < 0.01), while the risk of publication bias was not significant. Conclusion: Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection.
KW - AIDS
KW - COVID-19
KW - HIV
KW - meta-analysis
KW - mortality
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85134600278&partnerID=8YFLogxK
U2 - 10.1016/j.jiph.2022.05.006
DO - 10.1016/j.jiph.2022.05.006
M3 - Literature review
C2 - 35617829
AN - SCOPUS:85134600278
SN - 1876-0341
VL - 15
SP - 654
EP - 661
JO - Journal of Infection and Public Health
JF - Journal of Infection and Public Health
IS - 6
ER -