Simulation of cardiac action potential propagation using hybrid models

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Abstract

This paper investigates hybrid computational models as an approach to efficient simulation of electrical activity in cardiac tissue. In the hybrid approach, computational requirements are reduced by modelling only a local region using a detailed model, and embedding this within a simpler model of a larger tissue. We argue that the validity of this approach is dependent upon the method used to couple the different component models. We develop a simple coupling method for creating hybrid models in which the ionic Luo-Rudy phase 1 model is embedded within a tissue that uses the 3-variable Fenton-Karma model. The hybrid models are shown to preserve depolarisation fronts propagating through tissue as well as accurate action potential behaviour within embedded regions.
Original languageEnglish
Pages (from-to)633 -636
Number of pages4
JournalComputing in Cardiology
Volume37
Publication statusPublished - 2010

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