This paper investigates hybrid computational models as an approach to efficient simulation of electrical activity in cardiac tissue. In the hybrid approach, computational requirements are reduced by modelling only a local region using a detailed model, and embedding this within a simpler model of a larger tissue. We argue that the validity of this approach is dependent upon the method used to couple the different component models. We develop a simple coupling method for creating hybrid models in which the ionic Luo-Rudy phase 1 model is embedded within a tissue that uses the 3-variable Fenton-Karma model. The hybrid models are shown to preserve depolarisation fronts propagating through tissue as well as accurate action potential behaviour within embedded regions.
|Pages (from-to)||633 -636|
|Number of pages||4|
|Journal||Computing in Cardiology|
|Publication status||Published - 2010|