Individuals of African descent (AFD) are more susceptible to non-freezing cold injury (NFCI) than Caucasians (CAU) . This may be a consequence of lower skin blood flow during local cold exposure and subsequent rewarming in AFD , possibly due to a difference in endothelium function as acetylcholine (ACh)-induced vasodilatation is smaller in AFD than CAU on the non-glabrous finger and toe skin sites . It is known that prostaglandins produced by the enzyme cyclooxygenase (COX) mediate part of the ACh-induced vasodilator response  however in hypertensive individuals, COX inhibition results in augmented vasodilatation in response to ACh  demonstrating that COX can also promote vasoconstriction. Whether COX products are involved in the attenuated vasodilator response to ACh in healthy AFD  is not known. Therefore, the aim of the present study was to investigate the contribution of COX in both CAU and AFD to local application of ACh in foot and finger skin sites which are susceptible to NFCI.
|Journal||Extreme Physiology & Medicine|
|Issue number||Suppl 1|
|Publication status||Published - 14 Sep 2015|
|Event||15th International Conference on Environmental Ergonomics - Portsmouth, United Kingdom|
Duration: 28 Jun 2015 → 3 Jul 2015