SMRT has tissue-specific isoform profiles that include a form containing one CoRNR box

Stephen Short, Marianne Malartre, Colin Sharpe

Research output: Contribution to journalArticlepeer-review

Abstract

SMRT acts as a corepressor for a range of transcription factors. The amino-terminal part of the protein includes domains that mainly mediate transcriptional repression whilst the carboxy-terminal part includes domains that interact with nuclear receptors using up to three motifs called CoRNR boxes. The region of the SMRT primary transcript encoding the interaction domains is subject to alternative splicing that varies the inclusion of the third CoRNR box. The profile in mice includes an abundant, novel SMRT isoform that possesses just one CoRNR box. Mouse tissues therefore express SMRT isoforms containing one, two or three CoRNR boxes. In frogs, the SMRT isoform profile is tissue-specific. The mouse also shows distinct profiles generated by differential expression levels of the SMRT transcript isoforms. The formation of multiple SMRT isoforms and their tissue-specific regulation indicates a mechanism, whereby cells can define the repertoire of transcription factors regulated by SMRT.

Original languageEnglish
Pages (from-to)845-852
JournalBiochemical and Biophysical Research Communications
Volume334
Issue number3
Early online date12 Jul 2005
DOIs
Publication statusPublished - 2 Sep 2005

Keywords

  • Alternative Splicing
  • Amino Acid Motifs
  • Animals
  • DNA-Binding Proteins
  • Gene Expression Profiling
  • Humans
  • Mice
  • Nuclear Proteins
  • Nuclear Receptor Co-Repressor 1
  • Nuclear Receptor Co-Repressor 2
  • Protein Isoforms
  • Repressor Proteins
  • Tissue Distribution
  • Xenopus laevis

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