Stability in generic mitochondrial models

Pete Donnell, Murad Banaji, Stephen Baigent

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Abstract

In this paper, we use a variety of mathematical techniques to explore existence, local stability, and global stability of equilibria in abstract models of mitochondrial metabolism. The class of models constructed is defined by the biological description of the system, with minimal mathematical assumptions. The key features are an electron transport chain coupled to a process of charge translocation across a membrane. In the absence of charge translocation these models have previously been shown to behave in a very simple manner with a single, globally stable equilibrium. We show that with charge translocation the conclusion about a unique equilibrium remains true, but local and global stability do not necessarily follow. In sufficiently low dimensions - i.e. for short electron transport chains - it is possible to make claims about local and global stability of the equilibrium. On the other hand, for longer chains, these general claims are no longer valid. Some particular conditions which ensure stability of the equilibrium for chains of arbitrary length are presented.
Original languageEnglish
Pages (from-to)322-339
JournalJournal of Mathematical Chemistry
Volume46
Issue number2
Early online date23 Sep 2008
DOIs
Publication statusPublished - Aug 2009

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