Structure and evolution of insulins: implications for receptor binding

J. Murray-Rust; A. N. Mcleod; T. L. Blundell; S. P. Wood

doi:10.1002/bies.950140507

Structure and evolution of insulins: implications for receptor binding

J. Murray-Rust, A. N. Mcleod, T. L. Blundell, S. P. Wood

Institute of Life Sciences and Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.

Original language	English
Pages (from-to)	325-331
Journal	BioEssays
Volume	14
Issue number	5
DOIs	https://doi.org/10.1002/bies.950140507
Publication status	Published - 1 May 1992

Access to Document

10.1002/bies.950140507

Cite this

@article{eb25358bf1b24e8591bf22696bae7ea1,

title = "Structure and evolution of insulins: implications for receptor binding",

abstract = "Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common {\textquoteleft}insulin fold{\textquoteright} is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.",

author = "J. Murray-Rust and Mcleod, {A. N.} and Blundell, {T. L.} and Wood, {S. P.}",

year = "1992",

month = may,

day = "1",

doi = "10.1002/bies.950140507",

language = "English",

volume = "14",

pages = "325--331",

journal = "BioEssays",

issn = "0265-9247",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Structure and evolution of insulins

T2 - implications for receptor binding

AU - Murray-Rust, J.

AU - Mcleod, A. N.

AU - Blundell, T. L.

AU - Wood, S. P.

PY - 1992/5/1

Y1 - 1992/5/1

N2 - Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.

AB - Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.

U2 - 10.1002/bies.950140507

DO - 10.1002/bies.950140507

M3 - Article

SN - 0265-9247

VL - 14

SP - 325

EP - 331

JO - BioEssays

JF - BioEssays

IS - 5

ER -

Structure and evolution of insulins: implications for receptor binding

Abstract

Access to Document

Fingerprint

Cite this