Structure and evolution of insulins: implications for receptor binding

J. Murray-Rust; A. N. Mcleod; T. L. Blundell; S. P. Wood

doi:10.1002/bies.950140507

Structure and evolution of insulins: implications for receptor binding

J. Murray-Rust
, A. N. Mcleod
, T. L. Blundell
, S. P. Wood

Institute of Life Sciences and Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.

Original language	English
Pages (from-to)	325-331
Journal	BioEssays
Volume	14
Issue number	5
DOIs	https://doi.org/10.1002/bies.950140507
Publication status	Published - 1 May 1992

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title = "Structure and evolution of insulins: implications for receptor binding",

abstract = "Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common {\textquoteleft}insulin fold{\textquoteright} is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.",

author = "J. Murray-Rust and Mcleod, \{A. N.\} and Blundell, \{T. L.\} and Wood, \{S. P.\}",

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AU - Wood, S. P.

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AB - Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co-evolution of polypeptides and their receptors.

U2 - 10.1002/bies.950140507

DO - 10.1002/bies.950140507

M3 - Article

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SP - 325

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JO - BioEssays

JF - BioEssays

IS - 5

ER -

Structure and evolution of insulins: implications for receptor binding

Abstract

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