Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

J. Spencer; J. Amin; S. Callear; G. Tizzard; Simon J. Coles; Peter George Coxhead; Matthew John Guille

doi:10.1039/C1MT00017A

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

J. Spencer, J. Amin, S. Callear, G. Tizzard, Simon J. Coles, Peter George Coxhead, Matthew John Guille

Institute of Life Sciences and Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

Original language	English
Pages (from-to)	600-608
Journal	Metallomics
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/C1MT00017A
Publication status	Published - 2011

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10.1039/C1MT00017A

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title = "Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors",

abstract = "(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.",

author = "J. Spencer and J. Amin and S. Callear and G. Tizzard and Coles, \{Simon J.\} and Coxhead, \{Peter George\} and Guille, \{Matthew John\}",

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AU - Spencer, J.

AU - Amin, J.

AU - Callear, S.

AU - Tizzard, G.

AU - Coles, Simon J.

AU - Coxhead, Peter George

AU - Guille, Matthew John

PY - 2011

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AB - (E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

U2 - 10.1039/C1MT00017A

DO - 10.1039/C1MT00017A

M3 - Article

SN - 1756-5901

VL - 3

SP - 600

EP - 608

JO - Metallomics

JF - Metallomics

IS - 6

ER -

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

Abstract

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