Synthetic hydrogenases: Incorporation of an iron carbonyl thiolate into a designed peptide

Anne K. Jones*, Bruce R. Lichtenstein, Arnab Dutta, Gwyneth Gordon, P. Leslie Dutton

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

Abstract

[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases.

Original languageEnglish
Pages (from-to)14844-14845
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number48
Early online date13 Nov 2007
DOIs
Publication statusPublished - 1 Dec 2007

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