A systemic perspective could support an enterprise to integrate multiple organizational aspects to facilitate the implementation of sustainability in work practices. The study explores sustainability in SMEs work-practices from multiple stakeholder’ perspectives following a systemic approach to developing a systemic sustainability model proposal. This model intends to investigate sustainability’ relationships to uncover the business’s level of interactions, which results in a sustainability real-practice approach. In this context, the sociotechnical approach is essential for integrating sustainability in work-practices as it aims to balance technical and human systems to improve the quality of work context. Furthermore, an empirical study supports the creation of the model, which emphasizes the possible failure of the current sustainability approach implementation in practice. Overall, the systemic sustainability model intends to explore a systemic perspective to understand and decrease systems’ complexity in enterprises’ context to develop sustainability in work-practices. The analysis’ result emphasizes the importance of interactions to achieve sustainable development goals in a work-practices context.