Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

D. Martuszewska; B. Ljungberg; M. Johansson; G. Landberg; C. Oslakovic; B. Dahlback; Sassan Hafizi

doi:10.1371/journal.pone.0004350

Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

D. Martuszewska, B. Ljungberg, M. Johansson, G. Landberg, C. Oslakovic, B. Dahlback, Sassan Hafizi

Research output: Contribution to journal › Article › peer-review

Abstract

The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of human renal cell carcinoma (RCC), as well as probed the biological function of Tensin3. PRINCIPAL FINDINGS: Expression of Tensin2 and Tensin3 at mRNA and protein levels was largely absent in a panel of diverse human cancer cell lines. Quantitative RT-PCR analysis revealed mRNA expression of all four Tensin genes to be significantly downregulated in human kidney tumors (50-100% reduction versus normal kidney cortex; P

Original language	English
Pages (from-to)	e4350
Journal	PLoS One
Volume	4
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0004350
Publication status	Published - 2009

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title = "Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer",

abstract = "The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of human renal cell carcinoma (RCC), as well as probed the biological function of Tensin3. PRINCIPAL FINDINGS: Expression of Tensin2 and Tensin3 at mRNA and protein levels was largely absent in a panel of diverse human cancer cell lines. Quantitative RT-PCR analysis revealed mRNA expression of all four Tensin genes to be significantly downregulated in human kidney tumors (50-100% reduction versus normal kidney cortex; P",

author = "D. Martuszewska and B. Ljungberg and M. Johansson and G. Landberg and C. Oslakovic and B. Dahlback and Sassan Hafizi",

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T1 - Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

AU - Martuszewska, D.

AU - Ljungberg, B.

AU - Johansson, M.

AU - Landberg, G.

AU - Oslakovic, C.

AU - Dahlback, B.

AU - Hafizi, Sassan

PY - 2009

Y1 - 2009

N2 - The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of human renal cell carcinoma (RCC), as well as probed the biological function of Tensin3. PRINCIPAL FINDINGS: Expression of Tensin2 and Tensin3 at mRNA and protein levels was largely absent in a panel of diverse human cancer cell lines. Quantitative RT-PCR analysis revealed mRNA expression of all four Tensin genes to be significantly downregulated in human kidney tumors (50-100% reduction versus normal kidney cortex; P

AB - The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of human renal cell carcinoma (RCC), as well as probed the biological function of Tensin3. PRINCIPAL FINDINGS: Expression of Tensin2 and Tensin3 at mRNA and protein levels was largely absent in a panel of diverse human cancer cell lines. Quantitative RT-PCR analysis revealed mRNA expression of all four Tensin genes to be significantly downregulated in human kidney tumors (50-100% reduction versus normal kidney cortex; P

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DO - 10.1371/journal.pone.0004350

M3 - Article

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JO - PLoS One

JF - PLoS One

IS - 2

ER -

Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

Abstract

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