The critical impact of sex on preclinical alcohol research – insights from zebrafish

Murilo S. De Abreu; Matthew O. Parker; Allan V. Kalueff

doi:10.1016/j.yfrne.2022.101014

The critical impact of sex on preclinical alcohol research – insights from zebrafish

Murilo S. De Abreu, Matthew O. Parker, Allan V. Kalueff

School of Pharmacy & Biomedical Sciences

Moscow Institute of Physics and Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Sex is an important biological variable that is widely recognized in studies of alcohol-related effects. Complementing clinical and preclinical rodent research, the zebrafish (Danio rerio) is the second most used laboratory species, and a powerful model organism in biomedicine. Like clinical and rodent models, zebrafish demonstrate overt sex differences in alcohol-related responses. Collectively, this evidence shows that the zebrafish becomes a sensitive model species to further probe in-depth sex differences commonly reported in alcohol research.

Original language	English
Article number	101014
Number of pages	3
Journal	Frontiers in Neuroendocrinology
Volume	67
Early online date	27 Jul 2022
DOIs	https://doi.org/10.1016/j.yfrne.2022.101014
Publication status	Published - 1 Oct 2022

Keywords

sex differences
alcohol
animal models
zebrafish
pre-clinical research

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10.1016/j.yfrne.2022.101014

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title = "The critical impact of sex on preclinical alcohol research – insights from zebrafish",

abstract = "Sex is an important biological variable that is widely recognized in studies of alcohol-related effects. Complementing clinical and preclinical rodent research, the zebrafish (Danio rerio) is the second most used laboratory species, and a powerful model organism in biomedicine. Like clinical and rodent models, zebrafish demonstrate overt sex differences in alcohol-related responses. Collectively, this evidence shows that the zebrafish becomes a sensitive model species to further probe in-depth sex differences commonly reported in alcohol research.",

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AU - Kalueff, Allan V.

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N2 - Sex is an important biological variable that is widely recognized in studies of alcohol-related effects. Complementing clinical and preclinical rodent research, the zebrafish (Danio rerio) is the second most used laboratory species, and a powerful model organism in biomedicine. Like clinical and rodent models, zebrafish demonstrate overt sex differences in alcohol-related responses. Collectively, this evidence shows that the zebrafish becomes a sensitive model species to further probe in-depth sex differences commonly reported in alcohol research.

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KW - sex differences

KW - alcohol

KW - animal models

KW - zebrafish

KW - pre-clinical research

UR - https://linkinghub.elsevier.com/retrieve/pii/S0091302222000371

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DO - 10.1016/j.yfrne.2022.101014

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JF - Frontiers in Neuroendocrinology

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The critical impact of sex on preclinical alcohol research – insights from zebrafish

Abstract

Keywords

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