The DNA-dependent protein kinase (DNA-PK): more than just a case of making ends meet?

Richard Hill; Patrick W. Lee

doi:10.4161/cc.9.17.13043

The DNA-dependent protein kinase (DNA-PK): more than just a case of making ends meet?

Richard Hill, Patrick W. Lee

Dalhousie University

Research output: Contribution to journal › Article › peer-review

Abstract

The DNA-dependent protein kinase (DNA-PK) has a vital role in DNA double strand break repair and in mediating V(D)J recombination events. Over the years a body of data has implicated DNA-PK playing a significant role in mediating a p53-dependent apoptotic response under a range of cellular conditions including exposure to ionizing radiation (IR), environmental carcinogens, and chemotherapeutic agents or in cells that have critically shortened telomeres. These findings raise the hypothesis that DNA-PK acts as both a sensor and transmitter of DNA damage signals that directly impact cell fate. These many overlapping roles are discussed and considered in this review article.

Original language	English
Pages (from-to)	3460-3469
Number of pages	10
Journal	Cell Cycle
Volume	9
Issue number	17
DOIs	https://doi.org/10.4161/cc.9.17.13043
Publication status	Published - 1 Sept 2010
Externally published	Yes

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abstract = "The DNA-dependent protein kinase (DNA-PK) has a vital role in DNA double strand break repair and in mediating V(D)J recombination events. Over the years a body of data has implicated DNA-PK playing a significant role in mediating a p53-dependent apoptotic response under a range of cellular conditions including exposure to ionizing radiation (IR), environmental carcinogens, and chemotherapeutic agents or in cells that have critically shortened telomeres. These findings raise the hypothesis that DNA-PK acts as both a sensor and transmitter of DNA damage signals that directly impact cell fate. These many overlapping roles are discussed and considered in this review article.",

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AB - The DNA-dependent protein kinase (DNA-PK) has a vital role in DNA double strand break repair and in mediating V(D)J recombination events. Over the years a body of data has implicated DNA-PK playing a significant role in mediating a p53-dependent apoptotic response under a range of cellular conditions including exposure to ionizing radiation (IR), environmental carcinogens, and chemotherapeutic agents or in cells that have critically shortened telomeres. These findings raise the hypothesis that DNA-PK acts as both a sensor and transmitter of DNA damage signals that directly impact cell fate. These many overlapping roles are discussed and considered in this review article.

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The DNA-dependent protein kinase (DNA-PK): more than just a case of making ends meet?

Abstract

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