The effect of age on phenotype of primary rhegmatogenous retinal detachment

Mariantonia Ferrara; Mo Al-Zubaidy; Anna Song; Peter Avery; D. Alistair Laidlaw; Tom H. Williamson; David Yorston; David H. W. Steel; Atiq Babar; Kamaljit Singh Balaggan; Anthony G. Casswell; Aman Chandra; Stephen Charles; Timothy Cochrane; Niels Crama; Sandro Di Simplicio Cherubini; Abdallah A. Ellabban; John Ellis; Peter Van Etten; Marta S. Figueroa; Craig Goldsmith; Roxane J. Hillier; Edward Hughes; Tsveta Ivanova; Assad Jalil; Huw Jenkins; Ashraf Khan; D. Alistair Laidlaw; Yannick Le Mer; Angelina Meireles; Andrew H. C. Morris; Richard Newsom; Vasileios T. Papastavrou; Jonathan C. Park; Yashin D. Ramkissoon; Diego Sanchez-Chicharro; Richard Sheard; Jonathan Smith; Kurt Spiteri Cornish; David H. W. Steel; Vaughan Tanner; Deepak Vayalambrone; Tom H. Williamson; Stephen Winder; David Yorston

doi:10.1038/s41433-022-02061-y

The effect of age on phenotype of primary rhegmatogenous retinal detachment

Mariantonia Ferrara, Mo Al-Zubaidy, Anna Song, Peter Avery, D. Alistair Laidlaw, Tom H. Williamson, David Yorston, David H. W. Steel, Atiq Babar, Kamaljit Singh Balaggan, Anthony G. Casswell, Aman Chandra, Stephen Charles, Timothy Cochrane, Niels Crama, Sandro Di Simplicio Cherubini, Abdallah A. Ellabban, John Ellis, Peter Van Etten, Marta S. FigueroaCraig Goldsmith, Roxane J. Hillier, Edward Hughes, Tsveta Ivanova, Assad Jalil, Huw Jenkins, Ashraf Khan, D. Alistair Laidlaw, Yannick Le Mer, Angelina Meireles, Andrew H. C. Morris, Richard Newsom, Vasileios T. Papastavrou, Jonathan C. Park, Yashin D. Ramkissoon, Diego Sanchez-Chicharro, Richard Sheard, Jonathan Smith, Kurt Spiteri Cornish, David H. W. Steel, Vaughan Tanner, Deepak Vayalambrone, Tom H. Williamson, Stephen Winder, David Yorston

Research output: Contribution to journal › Article › peer-review

Abstract

Background: To evaluate the influence of age on the clinical characteristics of primary rhegmatogenous retinal detachments (RRD).

Methods: We conducted a retrospective review of a prospectively collected dataset. Data regarding adult patients (aged 16–100 years) who had undergone primary RRD repair, were extracted from two online databases. Baseline demographics, preoperative clinical characteristics and surgical management details were collected. Age-based groups (16–30, 30–39, 40–49, 50–59, 60–69, 70–79, ≥80) were compared using univariate analysis, with multivariate testing for interaction of age with sex, laterality and pseudophakia.

Results: In total, 8,133 eyes were analysed, of which the majority (59%) were in the 50–69 age-range peaking at 60, with a male predominance (64%). Myopia was significantly more frequent in patients aged <50 years. The presence of posterior vitreous detachment increased up to 50 years, then remained >95%. Foveal involvement, grade C proliferative vitreoretinopathy, total RD and greater RD extent were more common and progressively increased after 60 years, with worsening visual acuity. Isolated superior RRDs became more prevalent with age reaching a plateau in the age-range 50–69, before reducing again; conversely, isolated inferior RRDs were commoner in those <30, with a minimum in the 70–79 age-range. The incidence of fellow-eye RRD decreased linearly with age.

Conclusions: Age appeared a key variable in RRD phenotype influencing a wide range of RRD characteristics. The higher incidence of myopia, PVD absent and bilateral RRD in patients <40 years and the significant phenotypical differences in the under 40 and over 50 age-groups highlight that there are several discrete forms of RRD.

Original language	English
Number of pages	9
Journal	Eye
Early online date	26 Apr 2022
DOIs	https://doi.org/10.1038/s41433-022-02061-y
Publication status	Early online - 26 Apr 2022

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10.1038/s41433-022-02061-y

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Ferrara, M., Al-Zubaidy, M., Song, A., Avery, P., Laidlaw, D. A., Williamson, T. H., Yorston, D., Steel, D. H. W., Babar, A., Balaggan, K. S., Casswell, A. G., Chandra, A., Charles, S., Cochrane, T., Crama, N., Di Simplicio Cherubini, S., Ellabban, A. A., Ellis, J., Van Etten, P., ... Yorston, D. (2022). The effect of age on phenotype of primary rhegmatogenous retinal detachment. Eye. Advance online publication. https://doi.org/10.1038/s41433-022-02061-y

@article{aceef762ab984289ad63e7eb7c2c8b3c,

title = "The effect of age on phenotype of primary rhegmatogenous retinal detachment",

abstract = "Background: To evaluate the influence of age on the clinical characteristics of primary rhegmatogenous retinal detachments (RRD).Methods: We conducted a retrospective review of a prospectively collected dataset. Data regarding adult patients (aged 16–100 years) who had undergone primary RRD repair, were extracted from two online databases. Baseline demographics, preoperative clinical characteristics and surgical management details were collected. Age-based groups (16–30, 30–39, 40–49, 50–59, 60–69, 70–79, ≥80) were compared using univariate analysis, with multivariate testing for interaction of age with sex, laterality and pseudophakia.Results: In total, 8,133 eyes were analysed, of which the majority (59%) were in the 50–69 age-range peaking at 60, with a male predominance (64%). Myopia was significantly more frequent in patients aged <50 years. The presence of posterior vitreous detachment increased up to 50 years, then remained >95%. Foveal involvement, grade C proliferative vitreoretinopathy, total RD and greater RD extent were more common and progressively increased after 60 years, with worsening visual acuity. Isolated superior RRDs became more prevalent with age reaching a plateau in the age-range 50–69, before reducing again; conversely, isolated inferior RRDs were commoner in those <30, with a minimum in the 70–79 age-range. The incidence of fellow-eye RRD decreased linearly with age.Conclusions: Age appeared a key variable in RRD phenotype influencing a wide range of RRD characteristics. The higher incidence of myopia, PVD absent and bilateral RRD in patients <40 years and the significant phenotypical differences in the under 40 and over 50 age-groups highlight that there are several discrete forms of RRD.",

author = "Mariantonia Ferrara and Mo Al-Zubaidy and Anna Song and Peter Avery and Laidlaw, {D. Alistair} and Williamson, {Tom H.} and David Yorston and Steel, {David H. W.} and Atiq Babar and Balaggan, {Kamaljit Singh} and Casswell, {Anthony G.} and Aman Chandra and Stephen Charles and Timothy Cochrane and Niels Crama and {Di Simplicio Cherubini}, Sandro and Ellabban, {Abdallah A.} and John Ellis and {Van Etten}, Peter and Figueroa, {Marta S.} and Craig Goldsmith and Hillier, {Roxane J.} and Edward Hughes and Tsveta Ivanova and Assad Jalil and Huw Jenkins and Ashraf Khan and Laidlaw, {D. Alistair} and {Le Mer}, Yannick and Angelina Meireles and Morris, {Andrew H. C.} and Richard Newsom and Papastavrou, {Vasileios T.} and Park, {Jonathan C.} and Ramkissoon, {Yashin D.} and Diego Sanchez-Chicharro and Richard Sheard and Jonathan Smith and Cornish, {Kurt Spiteri} and Steel, {David H. W.} and Vaughan Tanner and Deepak Vayalambrone and Williamson, {Tom H.} and Stephen Winder and David Yorston",

year = "2022",

month = apr,

day = "26",

doi = "10.1038/s41433-022-02061-y",

language = "English",

journal = "Eye",

issn = "0950-222X",

publisher = "Nature Publishing Group",

}

Ferrara, M, Al-Zubaidy, M, Song, A, Avery, P, Laidlaw, DA, Williamson, TH, Yorston, D, Steel, DHW, Babar, A, Balaggan, KS, Casswell, AG, Chandra, A, Charles, S, Cochrane, T, Crama, N, Di Simplicio Cherubini, S, Ellabban, AA, Ellis, J, Van Etten, P, Figueroa, MS, Goldsmith, C, Hillier, RJ, Hughes, E, Ivanova, T, Jalil, A, Jenkins, H, Khan, A, Laidlaw, DA, Le Mer, Y, Meireles, A, Morris, AHC, Newsom, R, Papastavrou, VT, Park, JC, Ramkissoon, YD, Sanchez-Chicharro, D, Sheard, R, Smith, J, Cornish, KS, Steel, DHW, Tanner, V, Vayalambrone, D, Williamson, TH, Winder, S & Yorston, D 2022, 'The effect of age on phenotype of primary rhegmatogenous retinal detachment', Eye. https://doi.org/10.1038/s41433-022-02061-y

TY - JOUR

T1 - The effect of age on phenotype of primary rhegmatogenous retinal detachment

AU - Ferrara, Mariantonia

AU - Al-Zubaidy, Mo

AU - Song, Anna

AU - Avery, Peter

AU - Laidlaw, D. Alistair

AU - Williamson, Tom H.

AU - Yorston, David

AU - Steel, David H. W.

AU - Babar, Atiq

AU - Balaggan, Kamaljit Singh

AU - Casswell, Anthony G.

AU - Chandra, Aman

AU - Charles, Stephen

AU - Cochrane, Timothy

AU - Crama, Niels

AU - Di Simplicio Cherubini, Sandro

AU - Ellabban, Abdallah A.

AU - Ellis, John

AU - Van Etten, Peter

AU - Figueroa, Marta S.

AU - Goldsmith, Craig

AU - Hillier, Roxane J.

AU - Hughes, Edward

AU - Ivanova, Tsveta

AU - Jalil, Assad

AU - Jenkins, Huw

AU - Khan, Ashraf

AU - Laidlaw, D. Alistair

AU - Le Mer, Yannick

AU - Meireles, Angelina

AU - Morris, Andrew H. C.

AU - Newsom, Richard

AU - Papastavrou, Vasileios T.

AU - Park, Jonathan C.

AU - Ramkissoon, Yashin D.

AU - Sanchez-Chicharro, Diego

AU - Sheard, Richard

AU - Smith, Jonathan

AU - Cornish, Kurt Spiteri

AU - Steel, David H. W.

AU - Tanner, Vaughan

AU - Vayalambrone, Deepak

AU - Williamson, Tom H.

AU - Winder, Stephen

AU - Yorston, David

PY - 2022/4/26

Y1 - 2022/4/26

N2 - Background: To evaluate the influence of age on the clinical characteristics of primary rhegmatogenous retinal detachments (RRD).Methods: We conducted a retrospective review of a prospectively collected dataset. Data regarding adult patients (aged 16–100 years) who had undergone primary RRD repair, were extracted from two online databases. Baseline demographics, preoperative clinical characteristics and surgical management details were collected. Age-based groups (16–30, 30–39, 40–49, 50–59, 60–69, 70–79, ≥80) were compared using univariate analysis, with multivariate testing for interaction of age with sex, laterality and pseudophakia.Results: In total, 8,133 eyes were analysed, of which the majority (59%) were in the 50–69 age-range peaking at 60, with a male predominance (64%). Myopia was significantly more frequent in patients aged <50 years. The presence of posterior vitreous detachment increased up to 50 years, then remained >95%. Foveal involvement, grade C proliferative vitreoretinopathy, total RD and greater RD extent were more common and progressively increased after 60 years, with worsening visual acuity. Isolated superior RRDs became more prevalent with age reaching a plateau in the age-range 50–69, before reducing again; conversely, isolated inferior RRDs were commoner in those <30, with a minimum in the 70–79 age-range. The incidence of fellow-eye RRD decreased linearly with age.Conclusions: Age appeared a key variable in RRD phenotype influencing a wide range of RRD characteristics. The higher incidence of myopia, PVD absent and bilateral RRD in patients <40 years and the significant phenotypical differences in the under 40 and over 50 age-groups highlight that there are several discrete forms of RRD.

AB - Background: To evaluate the influence of age on the clinical characteristics of primary rhegmatogenous retinal detachments (RRD).Methods: We conducted a retrospective review of a prospectively collected dataset. Data regarding adult patients (aged 16–100 years) who had undergone primary RRD repair, were extracted from two online databases. Baseline demographics, preoperative clinical characteristics and surgical management details were collected. Age-based groups (16–30, 30–39, 40–49, 50–59, 60–69, 70–79, ≥80) were compared using univariate analysis, with multivariate testing for interaction of age with sex, laterality and pseudophakia.Results: In total, 8,133 eyes were analysed, of which the majority (59%) were in the 50–69 age-range peaking at 60, with a male predominance (64%). Myopia was significantly more frequent in patients aged <50 years. The presence of posterior vitreous detachment increased up to 50 years, then remained >95%. Foveal involvement, grade C proliferative vitreoretinopathy, total RD and greater RD extent were more common and progressively increased after 60 years, with worsening visual acuity. Isolated superior RRDs became more prevalent with age reaching a plateau in the age-range 50–69, before reducing again; conversely, isolated inferior RRDs were commoner in those <30, with a minimum in the 70–79 age-range. The incidence of fellow-eye RRD decreased linearly with age.Conclusions: Age appeared a key variable in RRD phenotype influencing a wide range of RRD characteristics. The higher incidence of myopia, PVD absent and bilateral RRD in patients <40 years and the significant phenotypical differences in the under 40 and over 50 age-groups highlight that there are several discrete forms of RRD.

UR - https://www.nature.com/articles/s41433-022-02061-y

U2 - 10.1038/s41433-022-02061-y

DO - 10.1038/s41433-022-02061-y

M3 - Article

SN - 0950-222X

JO - Eye

JF - Eye

ER -

The effect of age on phenotype of primary rhegmatogenous retinal detachment

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