TY - JOUR
T1 - The effects of acute multiple intraperitoneal injections of the GABAB receptor agonist baclofen on food intake in rats
AU - Patel, S.
AU - Ebenezer, Ivor
PY - 2008/12
Y1 - 2008/12
N2 - This study was undertaken to examine the effects of acute repeated administration of the GABAB receptor agonist baclofen on food intake in rats. In Experiment 1, the effects of repeated intraperitoneal (i.p.) injections of the GABAB receptor agonist baclofen (1 and 2 mg/kg) at 2 h intervals were investigated on food intake in non-deprived male Wistar rats. Both doses of baclofen significantly increased food intake after the 1st injection (P < 0.05), but had no effects on intake following the 2nd and 3rd injections. By contrast, in Experiment 2, diazepam (1 and 2 mg/kg, i.p.) significantly increased food intake (at least, P < 0.05) after each of 3 injection separated by 2 h in non-deprived rats. These data show that tolerance occurs to the hyperphagic effects of baclofen with acute multiple injections, and may have important implications for future studies investigating the effects of GABAB receptor agonists on food intake and energy homeostasis.
AB - This study was undertaken to examine the effects of acute repeated administration of the GABAB receptor agonist baclofen on food intake in rats. In Experiment 1, the effects of repeated intraperitoneal (i.p.) injections of the GABAB receptor agonist baclofen (1 and 2 mg/kg) at 2 h intervals were investigated on food intake in non-deprived male Wistar rats. Both doses of baclofen significantly increased food intake after the 1st injection (P < 0.05), but had no effects on intake following the 2nd and 3rd injections. By contrast, in Experiment 2, diazepam (1 and 2 mg/kg, i.p.) significantly increased food intake (at least, P < 0.05) after each of 3 injection separated by 2 h in non-deprived rats. These data show that tolerance occurs to the hyperphagic effects of baclofen with acute multiple injections, and may have important implications for future studies investigating the effects of GABAB receptor agonists on food intake and energy homeostasis.
U2 - 10.1016/j.ejphar.2008.10.059
DO - 10.1016/j.ejphar.2008.10.059
M3 - Article
SN - 0014-2999
VL - 601
SP - 106
EP - 110
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -