The effects of intraperitoneal administration of the GABAB receptor agonist baclofen on food intake in CFLP and C57BL/6 mice

The effects of the GABAB receptor agonist baclofen were investigated on food intake in non-deprived CFLP and C57BL/6 mice. In Experiment 1, baclofen (1–8mg /kg) administered i.p. to CFLP mice, produced a dose-related increase in food intake. The 4 and 8mg/kg doses produced significant increases in cumulative feeding when measure 120min after administration (at least P b 0.05, in each case). In Experiment 2, baclofen (1–10mg/kg), administered intraperitoneally (i.p.) to C57BL/6 mice, also produced a dose-related increase in food intake. The 4mg/kg dose of baclofen significantly increased cumulative food intake at 60min (P b 0.05), while the 2 and 4mg/kg doses significantly increased cumulative food intake at 120min (P b 0.01, in each case). The 10mg/kg dose was without effect. These data show that systemic administration of the GABAB agonist baclofen produces an increase in food consumption in two different strains of mice and extend previous observations made in rat to another rodent species.