Abstract
Liquid and semi-solid formulations adherent to the mouth, pharynx and oesophagus may provide mechanical protection, palliative relief and treat local disease. These mucosae also offer a substantial area of well-perfused tissue, perhaps suitable for systemic drug delivery. However, successful formulation design has been curtailed by the lack of a generally accepted method for evaluating mucoadhesive performance. Moreover, the mucoadhesive interaction is a complex phenomenon rather than a single-process bond. Therefore, an understanding of the relationship between mucoadhesive performance and the physicochemical properties must be elucidated to allow rational design of retentive dosage forms.
Original language | English |
---|---|
Pages (from-to) | 22 |
Number of pages | 1 |
Journal | Journal of Pharmacy and Pharmacology |
Volume | 54 |
Issue number | S1 |
DOIs | |
Publication status | Published - 2002 |