The factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus

Simon A. Young, Brian Carpenter, T. Nevell, J. Smart

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Liquid and semi-solid formulations adherent to the mouth, pharynx and oesophagus may provide mechanical protection, palliative relief and treat local disease. These mucosae also offer a substantial area of well-perfused tissue, perhaps suitable for systemic drug delivery. However, successful formulation design has been curtailed by the lack of a generally accepted method for evaluating mucoadhesive performance. Moreover, the mucoadhesive interaction is a complex phenomenon rather than a single-process bond. Therefore, an understanding of the relationship between mucoadhesive performance and the physicochemical properties must be elucidated to allow rational design of retentive dosage forms.
    Original languageEnglish
    Pages (from-to)22
    Number of pages1
    JournalJournal of Pharmacy and Pharmacology
    Volume54
    Issue numberS1
    DOIs
    Publication statusPublished - 2002

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