The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

G. Calabrese; J. Nesnas; Eugen Barbu; D. Fatouros; John Tsibouklis

doi:10.1016/j.drudis.2011.09.014

The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

G. Calabrese, J. Nesnas, Eugen Barbu, D. Fatouros, John Tsibouklis

Research output: Contribution to journal › Article › peer-review

Abstract

The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action – the subject of this review – is a challenge that is addressed by the development of innovative formulation strategies.

Original language	English
Pages (from-to)	153-159
Number of pages	7
Journal	Drug Discovery Today
Volume	17
Issue number	3-4
DOIs	https://doi.org/10.1016/j.drudis.2011.09.014
Publication status	Published - Feb 2012

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10.1016/j.drudis.2011.09.014

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abstract = "The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action – the subject of this review – is a challenge that is addressed by the development of innovative formulation strategies.",

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The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

Abstract

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