The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): An in vivo study

Robert G. Riley*, Keith L. Green, John D. Smart, John Tsibouklis, J. Alf Davis, Frank Hampson, Peter W. Dettmar, William R. Wilber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.

Original languageEnglish
Pages (from-to)1861-1867
Number of pages7
Issue number13
Publication statusPublished - 4 Jul 2001


  • C-poly(acrylic acid)
  • In vivo
  • Mucoadhesion
  • Polymer retention


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