The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): An in vivo study

Robert G. Riley; Keith L. Green; John D. Smart; John Tsibouklis; J. Alf Davis; Frank Hampson; Peter W. Dettmar; William R. Wilber

doi:10.1016/S0142-9612(00)00369-0

The gastrointestinal transit profile of ¹⁴C-labelled poly(acrylic acids): An in vivo study

Robert G. Riley^*, Keith L. Green, John D. Smart, John Tsibouklis, J. Alf Davis, Frank Hampson, Peter W. Dettmar, William R. Wilber

^*Corresponding author for this work

Institute of Life Sciences and Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

The gastrointestinal distribution profiles for three ¹⁴C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.

Original language	English
Pages (from-to)	1861-1867
Number of pages	7
Journal	Biomaterials
Volume	22
Issue number	13
DOIs	https://doi.org/10.1016/S0142-9612(00)00369-0
Publication status	Published - 4 Jul 2001

Keywords

C-poly(acrylic acid)
In vivo
Mucoadhesion
Polymer retention

Access to Document

10.1016/S0142-9612(00)00369-0

Cite this

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title = "The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): An in vivo study",

abstract = "The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.",

keywords = "C-poly(acrylic acid), In vivo, Mucoadhesion, Polymer retention",

author = "Riley, {Robert G.} and Green, {Keith L.} and Smart, {John D.} and John Tsibouklis and {Alf Davis}, J. and Frank Hampson and Dettmar, {Peter W.} and Wilber, {William R.}",

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AU - Alf Davis, J.

AU - Hampson, Frank

AU - Dettmar, Peter W.

AU - Wilber, William R.

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KW - C-poly(acrylic acid)

KW - In vivo

KW - Mucoadhesion

KW - Polymer retention

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