The influence of sex in the infection of mice C57BL/6 inoculated with Leishmania mexicana strain AZV

Jesús Maldonado, Marina Calcagno, Luisana Avilán

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of the sex was studied on the development of pathological alterations during experimental leishmaniasis, by observing the clinical evolution of the leg lesions and the immunohistopathological pattern in the skin, lymph node, liver and spleen of imbred mice C57BL/6 infected with the strain AZV of Leishmania mexicana. A divergence in the evolution of the lesion size was evident: In male specimens, there was a distinctive reduction, beginning in the ninth week of the study, whereas in females a progressive increase of the lesion was registered throughout the experiment up to the 13th week. The average size of the lesion was three times greater in females that in males. Significant differences (P<0.05) in the course of the lesion were observed. Differences in the histopathological patterns of skin samples of male and female mice were also observed. In females, the extension of the immunoreactivity with the antibodies anti- α-Leishmania (Ab-α-Leishmania was greater. In all lymph node samples of the infected limb, regardless of sex, the presence of the parasite was detected via immunoreactivity with Ab α-Leishmania; however, the same technique yielded no evidence of the presence of the parasite in non-infected limbs, liver or spleen on any one of the specimens studied. Summing up, the results indicate that under the used experimental conditions, sex influences in the development of experimental leishmaniasis in mice.

Translated title of the contributionThe influence of sex in the infection of mice C57BL/6 inoculated with Leishmania mexicana strain AZV
Original languageSpanish
Pages (from-to)542-547
Number of pages6
JournalRevista Cientifica
Volume14
Issue number6
Publication statusPublished - 2004

Keywords

  • Leishmania mexicana
  • Leishmaniasis
  • Mice C57BL/6
  • Sex

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