The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

Craig A. Williams; Owen W. Tomlinson; Lucy V. Chubbock; Daniel Stevens; Zoe Saynor; Patrick J. Oades; Alan Robert Barker

doi:10.1002/ppul.23896

The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

Craig A. Williams, Owen W. Tomlinson, Lucy V. Chubbock, Daniel Stevens, Zoe Saynor, Patrick J. Oades, Alan Robert Barker

Research output: Contribution to journal › Article › peer-review

157 Downloads (Pure)

Abstract

Background - Maximal cardiopulmonary exercise testing is recommended on an annual basis for children with cystic fibrosis (CF), due to a clinically useful prognostic information provided by maximal oxygen uptake (V̇O2_max). However, not all patients are able, or willing, to reach V̇O2_max, and therefore submaximal alternatives are required. This study explored the validity of the oxygen uptake efficiency slope (OUES) as a submaximal measure of V̇O2_max in children and adolescents with CF.

Methods - Data were collated from 72 cardiopulmonary exercise tests (36 CF, 36 controls), with OUES determined relative to maximal and submaximal parameters of exercise intensity, time and individual metabolic thresholds. Pearson’s correlation coefficients, independent t-tests and factorial ANOVAs were used to determine validity.

Results - Significant (p < 0.05) correlations with V̇O2_max were observed for most expressions of OUES, but were consistently weaker in CF (r = 0.30 – 0.47) when compared to CON (r = 0.58 – 0.89). Mean differences for all OUES parameters between groups were not significant (p > 0.05). When split by V̇O2_max tertiles, minimal significant differences were found between, and within, groups for OUES, indicating poor discrimination of V̇O2_max.

Conclusions - The OUES is not a valid (sub)maximal measure of V̇O2_max in children and adolescents with mild-to-moderate CF. Clinicians should continue to use maximal markers (i.e. V̇O2_max) of exercise capacity.

Original language	English
Pages (from-to)	36-42
Number of pages	7
Journal	Pediatric Pulmonology
Volume	53
Issue number	1
Early online date	24 Oct 2017
DOIs	https://doi.org/10.1002/ppul.23896
Publication status	Published - 1 Jan 2018

Keywords

oxygen uptake
exercise testing
adolescence
respiratory disease

Access to Document

10.1002/ppul.23896

The oxygen update efficiency slope
This is the peer reviewed version of the following article: Williams CA, Tomlinson OW, Chubbock LV, et al. The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis. Pediatr Pulmonol. 2017; 1–7. https://doi.org/10.1002/ppul.23896, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ppul.23896/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript (Post-print), 498 KB

http://onlinelibrary.wiley.com/doi/10.1002/ppul.23896/full

Cite this

@article{17f70b3a4e3444b6adc141221a4635aa,

title = "The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis",

abstract = "Background - Maximal cardiopulmonary exercise testing is recommended on an annual basis for children with cystic fibrosis (CF), due to a clinically useful prognostic information provided by maximal oxygen uptake ({\.V}O2max). However, not all patients are able, or willing, to reach {\.V}O2max, and therefore submaximal alternatives are required. This study explored the validity of the oxygen uptake efficiency slope (OUES) as a submaximal measure of {\.V}O2max in children and adolescents with CF. Methods - Data were collated from 72 cardiopulmonary exercise tests (36 CF, 36 controls), with OUES determined relative to maximal and submaximal parameters of exercise intensity, time and individual metabolic thresholds. Pearson{\textquoteright}s correlation coefficients, independent t-tests and factorial ANOVAs were used to determine validity.Results - Significant (p < 0.05) correlations with {\.V}O2max were observed for most expressions of OUES, but were consistently weaker in CF (r = 0.30 – 0.47) when compared to CON (r = 0.58 – 0.89). Mean differences for all OUES parameters between groups were not significant (p > 0.05). When split by {\.V}O2max tertiles, minimal significant differences were found between, and within, groups for OUES, indicating poor discrimination of {\.V}O2max.Conclusions - The OUES is not a valid (sub)maximal measure of {\.V}O2max in children and adolescents with mild-to-moderate CF. Clinicians should continue to use maximal markers (i.e. {\.V}O2max) of exercise capacity.",

keywords = "oxygen uptake, exercise testing, adolescence, respiratory disease",

author = "Williams, {Craig A.} and Tomlinson, {Owen W.} and Chubbock, {Lucy V.} and Daniel Stevens and Zoe Saynor and Oades, {Patrick J.} and Barker, {Alan Robert}",

year = "2018",

month = jan,

day = "1",

doi = "10.1002/ppul.23896",

language = "English",

volume = "53",

pages = "36--42",

journal = "Pediatric Pulmonology",

issn = "8755-6863",

publisher = "Wiley-Liss Inc.",

number = "1",

}

TY - JOUR

T1 - The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

AU - Williams, Craig A.

AU - Tomlinson, Owen W.

AU - Chubbock, Lucy V.

AU - Stevens, Daniel

AU - Saynor, Zoe

AU - Oades, Patrick J.

AU - Barker, Alan Robert

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background - Maximal cardiopulmonary exercise testing is recommended on an annual basis for children with cystic fibrosis (CF), due to a clinically useful prognostic information provided by maximal oxygen uptake (V̇O2max). However, not all patients are able, or willing, to reach V̇O2max, and therefore submaximal alternatives are required. This study explored the validity of the oxygen uptake efficiency slope (OUES) as a submaximal measure of V̇O2max in children and adolescents with CF. Methods - Data were collated from 72 cardiopulmonary exercise tests (36 CF, 36 controls), with OUES determined relative to maximal and submaximal parameters of exercise intensity, time and individual metabolic thresholds. Pearson’s correlation coefficients, independent t-tests and factorial ANOVAs were used to determine validity.Results - Significant (p < 0.05) correlations with V̇O2max were observed for most expressions of OUES, but were consistently weaker in CF (r = 0.30 – 0.47) when compared to CON (r = 0.58 – 0.89). Mean differences for all OUES parameters between groups were not significant (p > 0.05). When split by V̇O2max tertiles, minimal significant differences were found between, and within, groups for OUES, indicating poor discrimination of V̇O2max.Conclusions - The OUES is not a valid (sub)maximal measure of V̇O2max in children and adolescents with mild-to-moderate CF. Clinicians should continue to use maximal markers (i.e. V̇O2max) of exercise capacity.

AB - Background - Maximal cardiopulmonary exercise testing is recommended on an annual basis for children with cystic fibrosis (CF), due to a clinically useful prognostic information provided by maximal oxygen uptake (V̇O2max). However, not all patients are able, or willing, to reach V̇O2max, and therefore submaximal alternatives are required. This study explored the validity of the oxygen uptake efficiency slope (OUES) as a submaximal measure of V̇O2max in children and adolescents with CF. Methods - Data were collated from 72 cardiopulmonary exercise tests (36 CF, 36 controls), with OUES determined relative to maximal and submaximal parameters of exercise intensity, time and individual metabolic thresholds. Pearson’s correlation coefficients, independent t-tests and factorial ANOVAs were used to determine validity.Results - Significant (p < 0.05) correlations with V̇O2max were observed for most expressions of OUES, but were consistently weaker in CF (r = 0.30 – 0.47) when compared to CON (r = 0.58 – 0.89). Mean differences for all OUES parameters between groups were not significant (p > 0.05). When split by V̇O2max tertiles, minimal significant differences were found between, and within, groups for OUES, indicating poor discrimination of V̇O2max.Conclusions - The OUES is not a valid (sub)maximal measure of V̇O2max in children and adolescents with mild-to-moderate CF. Clinicians should continue to use maximal markers (i.e. V̇O2max) of exercise capacity.

KW - oxygen uptake

KW - exercise testing

KW - adolescence

KW - respiratory disease

U2 - 10.1002/ppul.23896

DO - 10.1002/ppul.23896

M3 - Article

SN - 8755-6863

VL - 53

SP - 36

EP - 42

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

IS - 1

ER -

The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

Abstract

Keywords

Access to Document

Fingerprint

Cite this