TY - JOUR
T1 - The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum
AU - Gogoi, Robindra N.
AU - Schubert, Frank
AU - Martinez-Barbera, Juan-Pedro
AU - Acampora, Dario
AU - Simeone, Antonio
AU - Lumsden, Andrew
PY - 2002
Y1 - 2002
N2 - We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otxgenes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic–parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.
AB - We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otxgenes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic–parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.
U2 - 10.1016/S0925-4773(02)00067-9
DO - 10.1016/S0925-4773(02)00067-9
M3 - Article
SN - 0925-4773
VL - 114
SP - 213
EP - 217
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 1-2
ER -