The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

Carina Venter; Kate Maslin; Veeresh Patil; Ramesh Kurukulaaratchy; Jane Grundy; Gillian Glasbey; Roger Twiselton; Taraneh Dean; Syed Hasan Arshad

doi:10.1111/pai.12616

The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

Carina Venter, Kate Maslin, Veeresh Patil, Ramesh Kurukulaaratchy, Jane Grundy, Gillian Glasbey, Roger Twiselton, Taraneh Dean, Syed Hasan Arshad

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Abstract

Background
The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.

Methods
The FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.

Results
In the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1,2,3 and 10 years respectively. At 10 years of age, 12/828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first ten years of life, 13/934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6/1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.

Conclusion
Peanut allergy appears to be stable over the first ten years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

Original language	English
Pages (from-to)	804-811
Journal	Pediatric Allergy and Immunology
Volume	27
Issue number	8
Early online date	19 Jul 2016
DOIs	https://doi.org/10.1111/pai.12616
Publication status	Published - Dec 2016

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The prevalence natural histroy and time trends
This is the pre-peer reviewed version of the following article: Venter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T. and Arshad, S. H. (2016), The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatr Allergy Immunol. Accepted Author Manuscript. doi:10.1111/pai.12616, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/pai.12616/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript (Post-print), 497 KB

http://doi.wiley.com/10.1111/pai.12616

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Venter, C., Maslin, K., Patil, V., Kurukulaaratchy, R., Grundy, J., Glasbey, G., Twiselton, R., Dean, T., & Arshad, S. H. (2016). The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatric Allergy and Immunology, 27(8), 804-811. https://doi.org/10.1111/pai.12616

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title = "The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart",

abstract = "BackgroundThe aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.MethodsThe FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.ResultsIn the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1,2,3 and 10 years respectively. At 10 years of age, 12/828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first ten years of life, 13/934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6/1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.ConclusionPeanut allergy appears to be stable over the first ten years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.",

author = "Carina Venter and Kate Maslin and Veeresh Patil and Ramesh Kurukulaaratchy and Jane Grundy and Gillian Glasbey and Roger Twiselton and Taraneh Dean and Arshad, {Syed Hasan}",

year = "2016",

month = dec,

doi = "10.1111/pai.12616",

language = "English",

volume = "27",

pages = "804--811",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell Munksgaard",

number = "8",

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Venter, C, Maslin, K, Patil, V, Kurukulaaratchy, R, Grundy, J, Glasbey, G, Twiselton, R, Dean, T & Arshad, SH 2016, 'The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart', Pediatric Allergy and Immunology, vol. 27, no. 8, pp. 804-811. https://doi.org/10.1111/pai.12616

TY - JOUR

T1 - The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

AU - Venter, Carina

AU - Maslin, Kate

AU - Patil, Veeresh

AU - Kurukulaaratchy, Ramesh

AU - Grundy, Jane

AU - Glasbey, Gillian

AU - Twiselton, Roger

AU - Dean, Taraneh

AU - Arshad, Syed Hasan

PY - 2016/12

Y1 - 2016/12

N2 - BackgroundThe aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.MethodsThe FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.ResultsIn the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1,2,3 and 10 years respectively. At 10 years of age, 12/828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first ten years of life, 13/934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6/1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.ConclusionPeanut allergy appears to be stable over the first ten years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

AB - BackgroundThe aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.MethodsThe FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.ResultsIn the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1,2,3 and 10 years respectively. At 10 years of age, 12/828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first ten years of life, 13/934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6/1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.ConclusionPeanut allergy appears to be stable over the first ten years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

U2 - 10.1111/pai.12616

DO - 10.1111/pai.12616

M3 - Article

SN - 0905-6157

VL - 27

SP - 804

EP - 811

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 8

ER -

The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

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