The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

X. Zhang; M. Varthi; S. Sykes; Charles Phillips; C. Warzecha; W. Zhu; A. Wyce; Alan Thorne; S. Berger; S. McMahon

doi:10.1016/j.molcel.2007.12.015

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

X. Zhang, M. Varthi, S. Sykes, Charles Phillips, C. Warzecha, W. Zhu, A. Wyce, Alan Thorne, S. Berger, S. McMahon

Thomas Jefferson University

Research output: Contribution to journal › Article › peer-review

209 Downloads (Pure)

Abstract

Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes coregulated with Polycomb genes was recently identified. The expression of this signature has been reported to identify tumors with the cancer stem cell phenotypes of aggressive growth, metastasis, and therapy resistance. Most members of this 11 gene signature encode proteins with well-defined roles in human cancer. However, the function of the signature member USP22 remains unknown. We report that USP22 is a previously uncharacterized subunit of the human SAGA transcriptional cofactor complex. Within SAGA, USP22 deubiquitylates histone H2B. Furthermore, USP22 is recruited to specific genes by activators such as the Myc oncoprotein, where it is required for transcription. In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle.

Original language	English
Pages (from-to)	102-111
Number of pages	10
Journal	Molecular Cell
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2007.12.015
Publication status	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.molcel.2007.12.015

1-s2.0-S1097276508000427-mainFinal published version, 251 KBLicence: CC BY-NC-SA

Cite this

@article{2942ffd1f2ac4b6abf7ad7e05fe64a55,

title = "The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression",

abstract = "Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes coregulated with Polycomb genes was recently identified. The expression of this signature has been reported to identify tumors with the cancer stem cell phenotypes of aggressive growth, metastasis, and therapy resistance. Most members of this 11 gene signature encode proteins with well-defined roles in human cancer. However, the function of the signature member USP22 remains unknown. We report that USP22 is a previously uncharacterized subunit of the human SAGA transcriptional cofactor complex. Within SAGA, USP22 deubiquitylates histone H2B. Furthermore, USP22 is recruited to specific genes by activators such as the Myc oncoprotein, where it is required for transcription. In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle.",

author = "X. Zhang and M. Varthi and S. Sykes and Charles Phillips and C. Warzecha and W. Zhu and A. Wyce and Alan Thorne and S. Berger and S. McMahon",

year = "2008",

doi = "10.1016/j.molcel.2007.12.015",

language = "English",

volume = "29",

pages = "102--111",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

AU - Zhang, X.

AU - Varthi, M.

AU - Sykes, S.

AU - Phillips, Charles

AU - Warzecha, C.

AU - Zhu, W.

AU - Wyce, A.

AU - Thorne, Alan

AU - Berger, S.

AU - McMahon, S.

PY - 2008

Y1 - 2008

N2 - Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes coregulated with Polycomb genes was recently identified. The expression of this signature has been reported to identify tumors with the cancer stem cell phenotypes of aggressive growth, metastasis, and therapy resistance. Most members of this 11 gene signature encode proteins with well-defined roles in human cancer. However, the function of the signature member USP22 remains unknown. We report that USP22 is a previously uncharacterized subunit of the human SAGA transcriptional cofactor complex. Within SAGA, USP22 deubiquitylates histone H2B. Furthermore, USP22 is recruited to specific genes by activators such as the Myc oncoprotein, where it is required for transcription. In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle.

AB - Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes coregulated with Polycomb genes was recently identified. The expression of this signature has been reported to identify tumors with the cancer stem cell phenotypes of aggressive growth, metastasis, and therapy resistance. Most members of this 11 gene signature encode proteins with well-defined roles in human cancer. However, the function of the signature member USP22 remains unknown. We report that USP22 is a previously uncharacterized subunit of the human SAGA transcriptional cofactor complex. Within SAGA, USP22 deubiquitylates histone H2B. Furthermore, USP22 is recruited to specific genes by activators such as the Myc oncoprotein, where it is required for transcription. In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle.

U2 - 10.1016/j.molcel.2007.12.015

DO - 10.1016/j.molcel.2007.12.015

M3 - Article

SN - 1097-2765

VL - 29

SP - 102

EP - 111

JO - Molecular Cell

JF - Molecular Cell

IS - 1

ER -

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this