The role of electrosprayed nanoapatites in guiding osteoblast behaviour

E. Thian, Zeeshan Ahmad, J. Huang, M. Edirisinghe, S. Jayasinghe, D. Ireland, R. Brooks, N. Rushton, W. Bonfield, S. Best

Research output: Contribution to journalArticlepeer-review


Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.
Original languageEnglish
Pages (from-to)1833-1843
Number of pages11
Issue number12
Publication statusPublished - Apr 2008


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