The role of electrosprayed nanoapatites in guiding osteoblast behaviour

E. Thian; Zeeshan Ahmad; J. Huang; M. Edirisinghe; S. Jayasinghe; D. Ireland; R. Brooks; N. Rushton; W. Bonfield; S. Best

doi:10.1016/j.biomaterials.2008.01.007

The role of electrosprayed nanoapatites in guiding osteoblast behaviour

E. Thian, Zeeshan Ahmad, J. Huang, M. Edirisinghe, S. Jayasinghe, D. Ireland, R. Brooks, N. Rushton, W. Bonfield, S. Best

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.

Original language	English
Pages (from-to)	1833-1843
Number of pages	11
Journal	Biomaterials
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/j.biomaterials.2008.01.007
Publication status	Published - Apr 2008

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title = "The role of electrosprayed nanoapatites in guiding osteoblast behaviour",

abstract = "Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.",

author = "E. Thian and Zeeshan Ahmad and J. Huang and M. Edirisinghe and S. Jayasinghe and D. Ireland and R. Brooks and N. Rushton and W. Bonfield and S. Best",

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T1 - The role of electrosprayed nanoapatites in guiding osteoblast behaviour

AU - Thian, E.

AU - Ahmad, Zeeshan

AU - Huang, J.

AU - Edirisinghe, M.

AU - Jayasinghe, S.

AU - Ireland, D.

AU - Brooks, R.

AU - Rushton, N.

AU - Bonfield, W.

AU - Best, S.

PY - 2008/4

Y1 - 2008/4

N2 - Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.

AB - Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.

U2 - 10.1016/j.biomaterials.2008.01.007

DO - 10.1016/j.biomaterials.2008.01.007

M3 - Article

SN - 0142-9612

VL - 29

SP - 1833

EP - 1843

JO - Biomaterials

JF - Biomaterials

IS - 12

ER -

The role of electrosprayed nanoapatites in guiding osteoblast behaviour

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