The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts

E. Thian; Zeeshan Ahmad; J. Huang; M. Edirisinghe; S. Jayasinghe; D. Ireland; R. Brooks; N. Rushton; W. Bonfield; S. Best

doi:10.1016/j.actbio.2009.08.012

The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts

E. Thian, Zeeshan Ahmad, J. Huang, M. Edirisinghe, S. Jayasinghe, D. Ireland, R. Brooks, N. Rushton, W. Bonfield, S. Best

Research output: Contribution to journal › Article › peer-review

Abstract

A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged.

Original language	English
Pages (from-to)	750-755
Journal	Acta Biomaterialia
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/j.actbio.2009.08.012
Publication status	Published - Mar 2010

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title = "The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts",

abstract = "A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged.",

author = "E. Thian and Zeeshan Ahmad and J. Huang and M. Edirisinghe and S. Jayasinghe and D. Ireland and R. Brooks and N. Rushton and W. Bonfield and S. Best",

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doi = "10.1016/j.actbio.2009.08.012",

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T1 - The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts

AU - Thian, E.

AU - Ahmad, Zeeshan

AU - Huang, J.

AU - Edirisinghe, M.

AU - Jayasinghe, S.

AU - Ireland, D.

AU - Brooks, R.

AU - Rushton, N.

AU - Bonfield, W.

AU - Best, S.

PY - 2010/3

Y1 - 2010/3

N2 - A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged.

AB - A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged.

U2 - 10.1016/j.actbio.2009.08.012

DO - 10.1016/j.actbio.2009.08.012

M3 - Article

SN - 1742-7061

VL - 6

SP - 750

EP - 755

JO - Acta Biomaterialia

JF - Acta Biomaterialia

IS - 3

ER -

The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts

Abstract

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