Projects per year
Abstract
Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.
| Original language | English |
|---|---|
| Pages (from-to) | 559-568 |
| Number of pages | 10 |
| Journal | Drug Development and Industrial Pharmacy |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2008 |
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Dive into the research topics of 'The spray drying of unfractionated heparin: optimization of the operating parameters'. Together they form a unique fingerprint.Projects
- 1 Finished
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Formulated muco-regulatory agents in the airways of patients with cystic fibrosis
Smith, J. & Shute, J.
1/09/02 → 31/08/06
Project: Research
Equipment
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Spray Drier (Buchi B290 Mini Spray Drier)
James Smith (Manager), Eugen Barbu (Manager) & James Smith (Operator)
Facility/equipment: Equipment