Topical diltiazem in management of chronic anal fissure: a review of the literature

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Anal fissure is a common painful anorectal condition which affects people of various age groups, and deteriorates their quality of life. Chronic anal fissure requires medical intervention either by pharmacotherapy or by surgery. Various pharmacological agents have been used in the treatment of chronic anal fissure with the aim of relaxation of internal anal-sphincter smooth muscle. Diltiazem is a calcium-channel blocker that has been tried in several clinical studies for management of chronic anal fissure. This review focuses on the available literature data on the use of topical diltiazem (cream, gel, ointment) in the treatment of chronic anal fissure in order to give an overall viewpoint of the work carried on in this field and the results obtained.
Original languageEnglish
Pages (from-to)923-934
Number of pages12
JournalClinical Investigation
Issue number10
Publication statusPublished - 21 Nov 2014

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