TY - JOUR
T1 - Towards boron neutron capture therapy
T2 - the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane
AU - Theodoropoulos, Dimitrios
AU - Rova, Aikaterini
AU - Smith, James R.
AU - Barbu, Eugen
AU - Calabrese, Gianpiero
AU - Vizirianakis, Ioannis S.
AU - Tsibouklis, John
AU - Fatouros, Dimitrios G.
PY - 2013/11/15
Y1 - 2013/11/15
N2 - Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.
AB - Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.
U2 - 10.1016/j.bmcl.2013.09.003
DO - 10.1016/j.bmcl.2013.09.003
M3 - Article
SN - 0960-894X
VL - 23
SP - 6161
EP - 6166
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 22
ER -
