Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane

Dimitrios Theodoropoulos; Aikaterini Rova; James R. Smith; Eugen Barbu; Gianpiero Calabrese; Ioannis S. Vizirianakis; John Tsibouklis; Dimitrios G. Fatouros

doi:10.1016/j.bmcl.2013.09.003

Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane

Dimitrios Theodoropoulos, Aikaterini Rova, James R. Smith, Eugen Barbu, Gianpiero Calabrese, Ioannis S. Vizirianakis, John Tsibouklis, Dimitrios G. Fatouros

Research output: Contribution to journal › Article › peer-review

Abstract

Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.

Original language	English
Pages (from-to)	6161-6166
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	23
Issue number	22
Early online date	9 Sept 2013
DOIs	https://doi.org/10.1016/j.bmcl.2013.09.003
Publication status	Published - 15 Nov 2013

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10.1016/j.bmcl.2013.09.003

Atomic Force Microscopy (AFM) NanoScope 4 MultiMode
James Smith (Manager)
School of Pharmacy & Biomedical Sciences
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Theodoropoulos, D., Rova, A., Smith, J. R., Barbu, E., Calabrese, G., Vizirianakis, I. S., Tsibouklis, J., & Fatouros, D. G. (2013). Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane. Bioorganic & Medicinal Chemistry Letters, 23(22), 6161-6166. https://doi.org/10.1016/j.bmcl.2013.09.003

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title = "Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane",

abstract = "Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.",

author = "Dimitrios Theodoropoulos and Aikaterini Rova and Smith, {James R.} and Eugen Barbu and Gianpiero Calabrese and Vizirianakis, {Ioannis S.} and John Tsibouklis and Fatouros, {Dimitrios G.}",

year = "2013",

month = nov,

day = "15",

doi = "10.1016/j.bmcl.2013.09.003",

language = "English",

volume = "23",

pages = "6161--6166",

journal = "Bioorganic & Medicinal Chemistry Letters",

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publisher = "Elsevier Limited",

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Theodoropoulos, D, Rova, A, Smith, JR, Barbu, E, Calabrese, G, Vizirianakis, IS, Tsibouklis, J & Fatouros, DG 2013, 'Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane', Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 22, pp. 6161-6166. https://doi.org/10.1016/j.bmcl.2013.09.003

Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane. / Theodoropoulos, Dimitrios; Rova, Aikaterini; Smith, James R. et al.
In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 22, 15.11.2013, p. 6161-6166.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Towards boron neutron capture therapy

T2 - the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane

AU - Theodoropoulos, Dimitrios

AU - Rova, Aikaterini

AU - Smith, James R.

AU - Barbu, Eugen

AU - Calabrese, Gianpiero

AU - Vizirianakis, Ioannis S.

AU - Tsibouklis, John

AU - Fatouros, Dimitrios G.

PY - 2013/11/15

Y1 - 2013/11/15

N2 - Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.

AB - Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.

U2 - 10.1016/j.bmcl.2013.09.003

DO - 10.1016/j.bmcl.2013.09.003

M3 - Article

SN - 0960-894X

VL - 23

SP - 6161

EP - 6166

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 22

ER -

Theodoropoulos D, Rova A, Smith JR, Barbu E, Calabrese G, Vizirianakis IS et al. Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane. Bioorganic & Medicinal Chemistry Letters. 2013 Nov 15;23(22):6161-6166. Epub 2013 Sept 9. doi: 10.1016/j.bmcl.2013.09.003

Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane

Abstract

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Atomic Force Microscopy (AFM) NanoScope 4 MultiMode

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