Towards carborane-functionalised structures for the treatment of brain cancer

Gianpiero Calabrese, Anis Daou, Eugen Barbu, John Tsibouklis

Research output: Contribution to journalLiterature reviewpeer-review

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Boron neutron capture therapy (BNCT) is a promising targeted chemoradiotherapeutic technique for the management of invasive brain tumors, such as glioblastoma multiforme (GBM). A prerequisite for effective BNCT is the selective targeting of tumour cells with 10B-rich therapeutic moieties. To this end, polyhedral boranes, especially carboranes, have received considerable attention because they combine a high boron content with relative low toxicity and metabolic inertness. Here, we review progress in the molecular design of recently investigated carborane derivatives in light of the widely accepted performance requirements for effective BNCT.
Original languageEnglish
Pages (from-to)63-75
JournalDrug Discovery Today
Issue number1
Early online date5 Sept 2017
Publication statusPublished - Jan 2018


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