Towards mixed sequence recognition by triple helix formation

Darren M. Gowers, Keith R. Fox*

*Corresponding author for this work

    Research output: Contribution to journalLiterature reviewpeer-review

    Abstract

    The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major limitation of this approach is that these structures are generally restricted to homopurine-homopyrimidine target sites. This review describes the strategies that have been employed to overcome this drawback and outlines the potential for triplex formation at mixed sequence DNA targets.

    Original languageEnglish
    Pages (from-to)1569-1577
    Number of pages9
    JournalNucleic Acids Research
    Volume27
    Issue number7
    DOIs
    Publication statusPublished - 1 Apr 1999

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