Towards mixed sequence recognition by triple helix formation

Darren M. Gowers, Keith R. Fox*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review


The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major limitation of this approach is that these structures are generally restricted to homopurine-homopyrimidine target sites. This review describes the strategies that have been employed to overcome this drawback and outlines the potential for triplex formation at mixed sequence DNA targets.

Original languageEnglish
Pages (from-to)1569-1577
Number of pages9
JournalNucleic Acids Research
Issue number7
Publication statusPublished - 1 Apr 1999


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