TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering

M. Fantini; M. Curto; F. De Crescenzio

doi:10.1007/978-3-319-45781-9_43

TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering

M. Fantini, M. Curto, F. De Crescenzio^*

^*Corresponding author for this work

University of Bologna

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The aim of regenerative medicine is replacing missing or damaged bone tissues with synthetic grafts based on porous interconnected scaffolds, which allow adhesion, growth, and proliferation of the human cells. The optimal design of such scaffolds, in the Bone Tissue Engineering field, should meet several geometrical requirements. First, they have to be customized to replicate the skeletal anatomy of the patient, and then they have to provide the proper trabecular structure to be successfully populated by the cells. Therefore, for modelling such scaffolds, specific design methods are needed to conceive extremely complex structures by controlling both macro and micro shapes. For this purpose, in the last years, the Computer Aided Design of Triply Periodic Minimal Surfaces has received considerable attention, since their presence in natural shapes and structures. In this work, we propose a method that exploit Triply Periodic Minimal Surfaces as unit cell for the development of customized trabecular scaffolds. The aim is to identify the mathematical parameters of these surfaces in order to obtain the target requirements of the bone grafts. For that reason, the method is implemented through a Generative Design tool that allow to interactively controlling both the porosity and the pores size of the scaffolds.

Original language	English
Title of host publication	Advances on Mechanics, Design Engineering and Manufacturing
Subtitle of host publication	Proceedings of the International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing (JCM 2016), 14-16 September, 2016, Catania, Italy
Editors	Benoit Eynard, Vincenzo Nigrelli, Salvatore Massimo Oliveri, Guillermo Peris-Fajarnes, Sergio Rizzuti
Publisher	Springer
Pages	425-435
Number of pages	11
ISBN (Electronic)	978-3-319-45781-9
ISBN (Print)	978-3-319-45780-2
DOIs	https://doi.org/10.1007/978-3-319-45781-9_43
Publication status	Published - Jan 2017
Event	8th International Joint Conference on Mechanics, Design Engineering and Advanced Manufacturing: JCM 2016 - Catania, Italy Duration: 14 Sept 2016 → 16 Sept 2016 http://www.jcm2016ct.com/

Publication series

Name	Lecture Notes in Mechanical Engineering
Publisher	Springer
ISSN (Print)	2195-4356
ISSN (Electronic)	2195-4364

Conference

Conference	8th International Joint Conference on Mechanics, Design Engineering and Advanced Manufacturing
Country/Territory	Italy
City	Catania
Period	14/09/16 → 16/09/16
Internet address	http://www.jcm2016ct.com/

Keywords

Bone tissue engineering
Generative design
Scaffold design
Triple periodic minimal surfaces

Access to Document

10.1007/978-3-319-45781-9_43

Cite this

Fantini, M., Curto, M., & De Crescenzio, F. (2017). TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering. In B. Eynard, V. Nigrelli, S. M. Oliveri, G. Peris-Fajarnes, & S. Rizzuti (Eds.), Advances on Mechanics, Design Engineering and Manufacturing: Proceedings of the International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing (JCM 2016), 14-16 September, 2016, Catania, Italy (pp. 425-435). (Lecture Notes in Mechanical Engineering). Springer. https://doi.org/10.1007/978-3-319-45781-9_43

Fantini, M. ; Curto, M. ; De Crescenzio, F. / TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering. Advances on Mechanics, Design Engineering and Manufacturing: Proceedings of the International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing (JCM 2016), 14-16 September, 2016, Catania, Italy. editor / Benoit Eynard ; Vincenzo Nigrelli ; Salvatore Massimo Oliveri ; Guillermo Peris-Fajarnes ; Sergio Rizzuti. Springer, 2017. pp. 425-435 (Lecture Notes in Mechanical Engineering).

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title = "TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering",

abstract = "The aim of regenerative medicine is replacing missing or damaged bone tissues with synthetic grafts based on porous interconnected scaffolds, which allow adhesion, growth, and proliferation of the human cells. The optimal design of such scaffolds, in the Bone Tissue Engineering field, should meet several geometrical requirements. First, they have to be customized to replicate the skeletal anatomy of the patient, and then they have to provide the proper trabecular structure to be successfully populated by the cells. Therefore, for modelling such scaffolds, specific design methods are needed to conceive extremely complex structures by controlling both macro and micro shapes. For this purpose, in the last years, the Computer Aided Design of Triply Periodic Minimal Surfaces has received considerable attention, since their presence in natural shapes and structures. In this work, we propose a method that exploit Triply Periodic Minimal Surfaces as unit cell for the development of customized trabecular scaffolds. The aim is to identify the mathematical parameters of these surfaces in order to obtain the target requirements of the bone grafts. For that reason, the method is implemented through a Generative Design tool that allow to interactively controlling both the porosity and the pores size of the scaffolds.",

keywords = "Bone tissue engineering, Generative design, Scaffold design, Triple periodic minimal surfaces",

author = "M. Fantini and M. Curto and {De Crescenzio}, F.",

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booktitle = "Advances on Mechanics, Design Engineering and Manufacturing",

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Fantini, M, Curto, M & De Crescenzio, F 2017, TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering. in B Eynard, V Nigrelli, SM Oliveri, G Peris-Fajarnes & S Rizzuti (eds), Advances on Mechanics, Design Engineering and Manufacturing: Proceedings of the International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing (JCM 2016), 14-16 September, 2016, Catania, Italy. Lecture Notes in Mechanical Engineering, Springer, pp. 425-435, 8th International Joint Conference on Mechanics, Design Engineering and Advanced Manufacturing, Catania, Italy, 14/09/16. https://doi.org/10.1007/978-3-319-45781-9_43

TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering. / Fantini, M.; Curto, M.; De Crescenzio, F.
Advances on Mechanics, Design Engineering and Manufacturing: Proceedings of the International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing (JCM 2016), 14-16 September, 2016, Catania, Italy. ed. / Benoit Eynard; Vincenzo Nigrelli; Salvatore Massimo Oliveri; Guillermo Peris-Fajarnes; Sergio Rizzuti. Springer, 2017. p. 425-435 (Lecture Notes in Mechanical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Fantini, M.

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N2 - The aim of regenerative medicine is replacing missing or damaged bone tissues with synthetic grafts based on porous interconnected scaffolds, which allow adhesion, growth, and proliferation of the human cells. The optimal design of such scaffolds, in the Bone Tissue Engineering field, should meet several geometrical requirements. First, they have to be customized to replicate the skeletal anatomy of the patient, and then they have to provide the proper trabecular structure to be successfully populated by the cells. Therefore, for modelling such scaffolds, specific design methods are needed to conceive extremely complex structures by controlling both macro and micro shapes. For this purpose, in the last years, the Computer Aided Design of Triply Periodic Minimal Surfaces has received considerable attention, since their presence in natural shapes and structures. In this work, we propose a method that exploit Triply Periodic Minimal Surfaces as unit cell for the development of customized trabecular scaffolds. The aim is to identify the mathematical parameters of these surfaces in order to obtain the target requirements of the bone grafts. For that reason, the method is implemented through a Generative Design tool that allow to interactively controlling both the porosity and the pores size of the scaffolds.

AB - The aim of regenerative medicine is replacing missing or damaged bone tissues with synthetic grafts based on porous interconnected scaffolds, which allow adhesion, growth, and proliferation of the human cells. The optimal design of such scaffolds, in the Bone Tissue Engineering field, should meet several geometrical requirements. First, they have to be customized to replicate the skeletal anatomy of the patient, and then they have to provide the proper trabecular structure to be successfully populated by the cells. Therefore, for modelling such scaffolds, specific design methods are needed to conceive extremely complex structures by controlling both macro and micro shapes. For this purpose, in the last years, the Computer Aided Design of Triply Periodic Minimal Surfaces has received considerable attention, since their presence in natural shapes and structures. In this work, we propose a method that exploit Triply Periodic Minimal Surfaces as unit cell for the development of customized trabecular scaffolds. The aim is to identify the mathematical parameters of these surfaces in order to obtain the target requirements of the bone grafts. For that reason, the method is implemented through a Generative Design tool that allow to interactively controlling both the porosity and the pores size of the scaffolds.

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Fantini M, Curto M, De Crescenzio F. TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering. In Eynard B, Nigrelli V, Oliveri SM, Peris-Fajarnes G, Rizzuti S, editors, Advances on Mechanics, Design Engineering and Manufacturing: Proceedings of the International Joint Conference on Mechanics, Design Engineering & Advanced Manufacturing (JCM 2016), 14-16 September, 2016, Catania, Italy. Springer. 2017. p. 425-435. (Lecture Notes in Mechanical Engineering). Epub 2016 Sept 3. doi: 10.1007/978-3-319-45781-9_43

TPMS for interactive modelling of trabecular scaffolds for bone tissue engineering

Abstract

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