TY - JOUR
T1 - Trends in sensitisation to aero and food allergens: comparison between different birth cohorts
AU - Dean, Tara
AU - Venter, Carina
AU - Kurukuralaatchy, R.
AU - Pereira, B.
AU - Matthews, S.
AU - Grundy, J.
AU - Clayton, C.
AU - Fenn, M.
AU - Higgins, Bernard
AU - Arshad, S.
PY - 2007/1
Y1 - 2007/1
N2 - RATIONALE: This study provides information on changes in sensitisation rates in children on the Isle of Wight.
METHODS: Three cohorts of children were recruited and underwent skin prick tests to a predefined panel of allergens (milk, egg, peanut, cod, house dust mite, cat and grass) by standard methodology. Wheat sensitisation was not analysed for Groups C and D due to different solutions used.
Group A: Children born 1989, tested at four years (1993).
Group B: Children born 2001/02, tested at three years (2004/05).
Group C: Children born 1989, tested at ten years (1999).
Group D: Children born in 1991/92, tested at 11 years (2002).
RESULTS: Sensitisation to predefined food allergens increased significantly from 1.8% in 1993 (Group A) to 4.2% in 2004 (Group B) (p = 0.008). When wheat-grass cross-reactors were excluded, increase was no longer significant (p = 0.31). In contrast sensitisation to aeroallergens showed a significant decrease from 14.8% to 10.9% (p = 0.006). Notable decreases were seen in HDM (p = 0.006), and grass, (p = 0.013). A significant rise, from 2.2% in 1999 (Group C) to 4.6% in 2002 (Group D), was observed in sensitisation to food allergens (p = 0.008). Sensitivity to peanut (p = 0.1023) and grass (p = 0.0115) rose significantly.
CONCLUSION: Prevalence of sensitivity to both food and aeroallergens was seen to be greater amongst older children than younger children. Amongst younger children we found a significant reduction in prevalence of sensitisation to aeroallergens. Amongst older children we found a significant increase in prevalence of sensitisation to food allergens.
AB - RATIONALE: This study provides information on changes in sensitisation rates in children on the Isle of Wight.
METHODS: Three cohorts of children were recruited and underwent skin prick tests to a predefined panel of allergens (milk, egg, peanut, cod, house dust mite, cat and grass) by standard methodology. Wheat sensitisation was not analysed for Groups C and D due to different solutions used.
Group A: Children born 1989, tested at four years (1993).
Group B: Children born 2001/02, tested at three years (2004/05).
Group C: Children born 1989, tested at ten years (1999).
Group D: Children born in 1991/92, tested at 11 years (2002).
RESULTS: Sensitisation to predefined food allergens increased significantly from 1.8% in 1993 (Group A) to 4.2% in 2004 (Group B) (p = 0.008). When wheat-grass cross-reactors were excluded, increase was no longer significant (p = 0.31). In contrast sensitisation to aeroallergens showed a significant decrease from 14.8% to 10.9% (p = 0.006). Notable decreases were seen in HDM (p = 0.006), and grass, (p = 0.013). A significant rise, from 2.2% in 1999 (Group C) to 4.6% in 2002 (Group D), was observed in sensitisation to food allergens (p = 0.008). Sensitivity to peanut (p = 0.1023) and grass (p = 0.0115) rose significantly.
CONCLUSION: Prevalence of sensitivity to both food and aeroallergens was seen to be greater amongst older children than younger children. Amongst younger children we found a significant reduction in prevalence of sensitisation to aeroallergens. Amongst older children we found a significant increase in prevalence of sensitisation to food allergens.
U2 - 10.1016/j.jaci.2006.11.414
DO - 10.1016/j.jaci.2006.11.414
M3 - Article
SN - 0091-6749
VL - 119
SP - S110
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1 Supp
ER -