Triplex-directed covalent cross-linking of a DNA nanostructure

David A Rusling; Iris S Nandhakumar; Tom Brown; Keith R Fox

doi:10.1039/c2cc35407a

Triplex-directed covalent cross-linking of a DNA nanostructure

David A Rusling, Iris S Nandhakumar, Tom Brown, Keith R Fox

Research output: Contribution to journal › Article › peer-review

Abstract

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Original language	English
Pages (from-to)	9592-9594
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	77
Early online date	10 Aug 2012
DOIs	https://doi.org/10.1039/c2cc35407a
Publication status	Published - 7 Oct 2012

Keywords

Base Sequence
Cross-Linking Reagents/chemistry
DNA/chemistry
Molecular Sequence Data
Nanostructures/chemistry

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10.1039/c2cc35407a

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title = "Triplex-directed covalent cross-linking of a DNA nanostructure",

abstract = "The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.",

keywords = "Base Sequence, Cross-Linking Reagents/chemistry, DNA/chemistry, Molecular Sequence Data, Nanostructures/chemistry",

author = "Rusling, {David A} and Nandhakumar, {Iris S} and Tom Brown and Fox, {Keith R}",

year = "2012",

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AU - Rusling, David A

AU - Nandhakumar, Iris S

AU - Brown, Tom

AU - Fox, Keith R

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AB - The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

KW - Base Sequence

KW - Cross-Linking Reagents/chemistry

KW - DNA/chemistry

KW - Molecular Sequence Data

KW - Nanostructures/chemistry

U2 - 10.1039/c2cc35407a

DO - 10.1039/c2cc35407a

M3 - Article

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VL - 48

SP - 9592

EP - 9594

JO - Chemical Communications

JF - Chemical Communications

IS - 77

ER -

Triplex-directed covalent cross-linking of a DNA nanostructure

Abstract

Keywords

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