Triplex-directed covalent cross-linking of a DNA nanostructure

David A Rusling, Iris S Nandhakumar, Tom Brown, Keith R Fox

Research output: Contribution to journalArticlepeer-review


The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Original languageEnglish
Pages (from-to)9592-9594
Number of pages3
JournalChemical Communications
Issue number77
Early online date10 Aug 2012
Publication statusPublished - 7 Oct 2012


  • Base Sequence
  • Cross-Linking Reagents/chemistry
  • DNA/chemistry
  • Molecular Sequence Data
  • Nanostructures/chemistry


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