Two are better than one

S. Halford, Darren Gowers, R. Sessions

Research output: Contribution to journalArticlepeer-review


A crystal structure of a tetrameric restriction enzyme, NgoMIV, bound to two DNA duplexes has been determined. Two subunits contact each duplex in much the same manner as a dimeric restriction enzyme recognizing a single site, but the dimeric units are packed back-to-back, placing the duplexes on opposite sides of the tetramer. Interaction with two recognition sites, presumably via looping, enhances NgoMIV activity.
Original languageEnglish
Pages (from-to)705-707
Number of pages3
JournalNature Structural Biology
Issue number9
Publication statusPublished - 2000


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